Association between serotonin transporter gene polymorphisms and increased suicidal risk among HIV positive patients in Uganda

Simple item page
dc.contributor.authorKalungi, Allan
dc.contributor.authorSeedat, Soraya
dc.contributor.authorHemmings, Sian M. J.
dc.contributor.authorMerwe, Lize van der
dc.contributor.authorJoloba, Moses L.
dc.contributor.authorNanteza, Ann
dc.contributor.authorNakassujja, Noeline
dc.contributor.authorBirabwa, Harriet
dc.contributor.authorSerwanga, Jennifer
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorKinyanda, Eugene
dc.date.accessioned2022-12-18T12:28:55Z
dc.date.available2022-12-18T12:28:55Z
dc.date.issued2017
dc.description.abstractPersons living with HIV/AIDS (PLWHA) are at an increased risk of suicide. Increased suicidal risk is a predictor of future attempted and completed suicides and has been associated with poor quality of life and poor adherence with antiretroviral therapy. Clinical risk factors have low predictive value for suicide, hence the interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. The serotonin transporter gene has previously been implicated in the aetiology of increased suicidal risk in non-HIV infected study populations and its variations may provide a platform for identifying genetic risk for suicidality among PLWHA. The present cross-sectional study aimed at identifying two common genetic variants of the serotonin transporter gene and their association with increased suicidal risk among human immunodeficiency virus (HIV)-positive adults in Uganda. Results: The prevalence of increased suicidal risk (defined as moderate to high risk suicidality on the suicidality module of the Mini Neuropsychiatric Interview (M.I.N.I) was 3.3% (95% CI, 2.0–5.3). The 5-HTTLPR was found to be associated with increased suicidal risk before Bonferroni correction (p-value = 0.0174). A protective effect on increased suicidal risk was found for the 5-HTTLPR/rs25531 SA allele (p-value = 0.0046)- which directs reduced expression of the serotonin transporter gene (5-HTT). Conclusion: The SA allele at the 5-HTTLPR/rs25531 locus is associated with increased suicidal risk among Ugandan PLWHA. Further studies are needed to validate this finding in Ugandan and other sub-Saharan samples.en_US
dc.identifier.citationKalungi, A., Seedat, S., Hemmings, S. M., Van der Merwe, L., Joloba, M. L., Nanteza, A., ... & Kinyanda, E. (2017). Association between serotonin transporter gene polymorphisms and increased suicidal risk among HIV positive patients in Uganda. BMC genetics, 18(1), 1-9. DOI 10.1186/s12863-017-0538-yen_US
dc.identifier.other10.1186/s12863-017-0538-y
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/6398
dc.language.isoenen_US
dc.publisherBMC geneticsen_US
dc.subjectSuicidal risken_US
dc.subjectSerotonin transporter (5-HTT) gene polymorphismsen_US
dc.subjectHIV/Aidsen_US
dc.subjectUgandaen_US
dc.titleAssociation between serotonin transporter gene polymorphisms and increased suicidal risk among HIV positive patients in Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Association between serotonin transporter.pdf
Size:
457.38 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences