Viruses associated with measles-like illnesses in Uganda

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dc.contributor.authorNamuwulya, Prossy
dc.contributor.authorShirin, Ashraf
dc.contributor.authorMarc, Niebel
dc.contributor.authorSsekagiri, Alfred
dc.contributor.authorTushabe, Phionah
dc.contributor.authorKakooza, Proscovia
dc.contributor.authorLily, Tong
dc.contributor.authorBukenya, Henry
dc.contributor.authorHanna, Jerome
dc.contributor.authorChris, Davis
dc.contributor.authorBirungi, Molly
dc.contributor.authorTuryahabwe, Irene
dc.contributor.authorMugaga, Arnold
dc.contributor.authorEliku, James Peter
dc.contributor.authorAine, Francis
dc.contributor.authorNakabazzi, Lucy
dc.contributor.authorNsubuga, Fred
dc.contributor.authorKatushabe, Edson
dc.contributor.authorKisakye, Annet
dc.contributor.authorAmpeire, Immaculate
dc.contributor.authorNanteza, Ann
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorBakamutumaho, Barnabas
dc.contributor.authorNsamba, Peninah
dc.contributor.authorKazibwe, Anne
dc.contributor.authorAna, da Silva Filipe
dc.contributor.authorTweyongyere, Robert
dc.contributor.authorBwogi, Josephine
dc.contributor.authorThomson, Emma C.
dc.date.accessioned2025-03-09T20:48:49Z
dc.date.available2025-03-09T20:48:49Z
dc.date.issued2024
dc.description.abstractObjectives In this study, we investigated the causes of measles-like illnesses (MLI) in the Uganda national surveillance program in order to inform diagnostic assay selection and vaccination strategies. Methods We used metagenomic next-generation sequencing (M-NGS) on the Illumina platform to identify viruses associated with MLI (defined as fever and rash in the presence of either cough, coryza or conjunctivitis) in patient samples that had tested IgM negative for measles between 2010 and 2019. Results Viral genomes were identified in 87/271 (32%) of samples, of which 44/271 (16%) contained 12 known viral pathogens. Expected viruses included rubella, human parvovirus B19, Epstein Barr virus, human herpesvirus 6B, human cytomegalovirus, varicella zoster virus and measles virus (detected within the seronegative window-period of infection) and the blood-borne hepatitis B virus. We also detected Saffold virus, human parvovirus type 4, the human adenovirus C2 and vaccine-associated poliovirus type 1. Conclusions The study highlights the presence of undiagnosed viruses causing MLI in Uganda, including vaccine-preventable illnesses. NGS can be used to monitor common viral infections at a population level, especially in regions where such infections are prevalent, including low and middle income countries to guide vaccination policy and optimize diagnostic assays.
dc.identifier.citationNamuwulya, P., Ashraf, S., Niebel, M., Ssekagiri, A., Tushabe, P., Kakooza, P., ... & Thomson, E. C. (2024). Viruses associated with measles-like illnesses in Uganda. Journal of Infection, 88(5), 106148. https://doi.org/10.1016/j.jinf.2024.106148
dc.identifier.urihttps://doi.org/10.1016/j.jinf.2024.106148
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/10095
dc.language.isoen
dc.publisherJournal of Infection
dc.titleViruses associated with measles-like illnesses in Uganda
dc.typeArticle
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