Paradigm shift in the diagnosis of peste des petits ruminants: scoping review

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dc.contributor.authorKinimi, Edson
dc.contributor.authorOdongo, Steven
dc.contributor.authorMuyldermans, Serge
dc.contributor.authorKock, Richard
dc.contributor.authorMisinzo, Gerald
dc.date.accessioned2023-06-14T15:55:09Z
dc.date.available2023-06-14T15:55:09Z
dc.date.issued2020
dc.description.abstractPeste des petits ruminants virus causes a highly contagious disease, which poses enormous economic losses in domestic animals and threatens the conservation of wild herbivores. Diagnosis remains a cornerstone to the Peste des petits ruminants Global Control and Eradication Strategy, an initiative of the World Organisation for Animal Health and the Food and Agriculture Organisation. The present review presents the peste des petits ruminants diagnostic landscape, including the practicality of commercially available diagnostic tools, prototype tests and opportunities for new technologies. The most common peste des petits ruminants diagnostic tools include; agar gel immunodiffusion, counter-immunoelectrophoresis, enzyme-linked immunosorbent assays, reverse transcription polymerase chain reaction either gel-based or real-time, reverse transcription loop-mediated isothermal amplification, reverse transcription recombinase polymerase amplification assays, immunochromatographic lateral flow devices, luciferase immunoprecipitation system and pseudotype-based assays. These tests vary in their technical demands, but all require a laboratory with exception of immunochromatographic lateral flow and possibly reverse transcription loop-mediated isothermal amplification and reverse transcription recombinase polymerase amplification assays. Thus, we are proposing an efficient integration of diagnostic tests for rapid and correct identification of peste des petits ruminants in endemic zones and to rapidly confirm outbreaks. Deployment of pen-side tests will improve diagnostic capacity in extremely remote settings and susceptible wildlife ecosystems, where transportation of clinical samples in the optimum cold chain is unreliable.en_US
dc.identifier.citationKinimi, E., Odongo, S., Muyldermans, S., Kock, R., & Misinzo, G. (2020). Paradigm shift in the diagnosis of peste des petits ruminants: scoping review. Acta Veterinaria Scandinavica, 62(1), 1-14.https://doi.org/10.1186/s13028-020-0505-xen_US
dc.identifier.issn1751-0147
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8927
dc.language.isoenen_US
dc.publisherActa Veterinaria Scandinavicaen_US
dc.subjectPeste des petits ruminantsen_US
dc.subjectParadigmen_US
dc.subjectDomestic animalsen_US
dc.titleParadigm shift in the diagnosis of peste des petits ruminants: scoping reviewen_US
dc.typeArticleen_US
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