Accuracy of Two Malaria Rapid Diagnostic Tests (RDTS) for Initial Diagnosis and Treatment Monitoring in a High Transmission Setting in Uganda

Simple item page
dc.contributor.authorMbabazi, Phoebe
dc.contributor.authorHopkins, Heidi
dc.contributor.authorOsilo, Emmanuel
dc.contributor.authorKalungu, Michael
dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorKamya, Moses R.
dc.date.accessioned2022-01-12T07:36:37Z
dc.date.available2022-01-12T07:36:37Z
dc.date.issued2015
dc.description.abstractMalaria rapid diagnostic tests (RDTs) may improve fever management in areas without microscopy. We compared the accuracy of histidine-rich protein 2 (HRP2) and Plasmodium lactate dehydrogenase (pLDH)-based RDTs, using expert microscopy as a gold standard, for initial diagnosis, treatment monitoring, and diagnosis of recurrent malaria in a cohort of children followed longitudinally in a high transmission area in Uganda. For 305 initial fever episodes, sensitivity was 98% for HRP2 and 87% for pLDH, whereas specificity was 55% and 96%, respectively. The HRP2 gave 51% false-positive results on Day 28, whereas pLDH gave no false positives after Day 7. For 59 recurrent fever episodes during follow-up, sensitivity was 100% for HRP2 and 91% for pLDH, whereas specificity was 33% and 100%, respectively. The HRP2-based RDTs are useful for initial diagnosis of malaria caused by superior sensitivity; however, as a result of superior specificity, pLDH-based RDTs are more appropriate to monitor treatment and diagnose recurrent malaria.en_US
dc.identifier.citationMbabazi, P., Hopkins, H., Osilo, E., Kalungu, M., Byakika-Kibwika, P., & Kamya, M. R. (2015). Accuracy of two malaria rapid diagnostic tests (RDTS) for initial diagnosis and treatment monitoring in a high transmission setting in Uganda. The American journal of tropical medicine and hygiene, 92(3), 5. doi:10.4269/ajtmh.14-018030.en_US
dc.identifier.other10.4269/ajtmh.14-0180
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1198
dc.language.isoenen_US
dc.publisherThe American journal of tropical medicine and hygieneen_US
dc.subjectMalaria Rapid Diagnostic Tests (RDTS)en_US
dc.subjectTreatment Monitoringen_US
dc.subjectTransmission Settingen_US
dc.subjectUgandaen_US
dc.titleAccuracy of Two Malaria Rapid Diagnostic Tests (RDTS) for Initial Diagnosis and Treatment Monitoring in a High Transmission Setting in Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Accuracy of Two Malaria Rapid Diagnostic Tests (RDTS) for Initial Diagnosis and Treatment.pdf
Size:
640.61 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences