HIV-1-Neutralizing IgA Detected in Genital Secretions of Highly HIV- 1-Exposed Seronegative Women on Oral Preexposure Prophylaxis

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dc.contributor.authorLund, Jennifer M.
dc.contributor.authorBroliden, Kristina
dc.contributor.authorPyra, Maria N.
dc.contributor.authorThomas, Katherine K.
dc.contributor.authorDonnell, Deborah
dc.contributor.authorIrungu, Elizabeth
dc.contributor.authorMuwonge, Timothy R.
dc.contributor.authorMugo, Nelly
dc.contributor.authorManohar, Madhuri
dc.contributor.authorJansson, Marianne
dc.contributor.authorMackelprang, Romel
dc.contributor.authorMarzinke, Mark A.
dc.contributor.authorBaeten, Jared M.
dc.contributor.authorLingappa, Jairam R.
dc.date.accessioned2023-02-07T19:52:48Z
dc.date.available2023-02-07T19:52:48Z
dc.date.issued2016
dc.description.abstractAlthough nonhuman primate studies have shown that simian immunodeficiency virus/simian-human immunodeficiency virus (SIV/SHIV) exposure during preexposure prophylaxis (PrEP) with oral tenofovir can induce SIV immunity without productive infection, this has not been documented in humans. We evaluated cervicovaginal IgA in Partners PrEP Study participants using a subtype C primary isolate and found that women on PrEP had IgA with higher average human immunodeficiency virus type 1 (HIV-1)-neutralizing magnitude than women on placebo (33% versus 7%; P 0.008). Using a cutoff of>90% HIV-1 neutralization, 19% of women on-PrEP had HIV-1-neutralizing IgA compared to 0% of women on placebo (P 0.09). We also estimated HIV-1 exposure and found that the proportion of women with HIV-1-neutralizing IgA was associated with the level of HIV-1 exposure (P 0.04). Taken together, our data suggest that PrEP and high levels of exposure to HIV may each enhance mucosal HIV-1-specific humoral immune responses in sexually exposed but HIV-1-uninfected individuals.en_US
dc.identifier.citationLund JM, Broliden K, Pyra MN, Thomas KK, Donnell D, Irungu E, Muwonge TR, Mugo N, Manohar M, Jansson M, Mackelprang R, Marzinke MA, Baeten JM, Lingappa JR, for the Partners PrEP Study. 2016. HIV-1-neutralizing IgA detected in genital secretions of highly HIV-1-exposed seronegative women on oral preexposure prophylaxis. J Virol 90:9855–9861. doi:10.1128/JVI.01482-16.en_US
dc.identifier.other10.1128/JVI.01482-16.
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7640
dc.language.isoenen_US
dc.publisherJournal of virologyen_US
dc.subjectHIV-1-Neutralizing IgAen_US
dc.subjectGenital Secretionsen_US
dc.subjectSeronegative Womenen_US
dc.subjectOral Preexposure Prophylaxisen_US
dc.titleHIV-1-Neutralizing IgA Detected in Genital Secretions of Highly HIV- 1-Exposed Seronegative Women on Oral Preexposure Prophylaxisen_US
dc.typeArticleen_US
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