Effect of chronic alcohol consumption on the red blood cell count and RBC indices in the HIV infected patients on d4T/3TC/NVP drug regimen in Uganda

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dc.contributor.authorBbosa, Godfrey S.
dc.contributor.authorKyegombe, David B.
dc.contributor.authorAnokbonggo, William W.
dc.contributor.authorLubega, Aloysius
dc.contributor.authorMugisha, Apollo
dc.contributor.authorOgwal-Okeng, Jasper
dc.date.accessioned2022-05-02T22:51:20Z
dc.date.available2022-05-02T22:51:20Z
dc.date.issued2013
dc.description.abstractAlcohol consumption is common problem in Uganda. Among the types of alcohols consumed include beers, spirits, liqueurs, wines and traditional brew. These alcohols are easily accessible and consumed by many people including the HIV infected patients who are on the d4T/3TC/NVP regimen. The aim of this study was to determine the effect of chronic alcohol intake on the red blood cell count (RBC) and the RBC indices in the HIV-infected patients on d4T/3TC/NVP regimen. It was a case control study that used a repeated measures design model where serial measurements of the red blood cell count (RBC) and RBC indices were determined at 3 month interval for 9 months. A total of 41 HIV infected patients were recruited and grouped into two arms; the control group had 21 patients and the chronic alcohol group had 20 patients. The RBC and RBC indices of the whole blood were determined using automated hematological Coulter CBC-5 Hematology Analyzer system using standard procedures. The data was sorted into alcohol-use self reporting by WHO AUDIT tool and alcohol-use biomarkers groups. It was analysed using the SAS 2003 version 9.1 statistical package with the repeated measures fixed model. The means were compared using the student t-test. The mean MCV and MCH values in the chronic alcohol use group were higher than in the control group and there was a significant difference between the 2 groups (p<0.05) for both the WHO AUDIT tool group and chronic alcohol use biomarkers group. The mean RBC count, Hct, HGB and MCHC values in both the control and chronic alcohol use groups were within the normal reference ranges for both groups though the trend was lower in alcohol group. Chronic alcohol use affects the RBC and RBC indices in the HIV infected patients on d4T/3TC/NVP treatment regimen.en_US
dc.identifier.citationBbosa, G. S., Kyegombe, D. B., Anokbonggo, W. W., Lubega, A., Mugisha, A., & Ogwal-Okeng, J. (2013). Effect of chronic alcohol consumption on the red blood cell count and RBC indices in the HIV infected patients on d4T/3TC/NVP drug regimen in Uganda. doi: 10.5455/2319-2003.ijbcp20131004en_US
dc.identifier.other10.5455/2319-2003.ijbcp20131004
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3179
dc.language.isoenen_US
dc.publisherIJBCP International Journal of Basic & Clinical Pharmacologyen_US
dc.subjectChronic alcohol useen_US
dc.subjectRBCen_US
dc.subjectRBC indicesen_US
dc.subjectHIV infected patientsen_US
dc.subjectARVsen_US
dc.titleEffect of chronic alcohol consumption on the red blood cell count and RBC indices in the HIV infected patients on d4T/3TC/NVP drug regimen in Ugandaen_US
dc.typeArticleen_US
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