Identification of restriction endonuclease with potential ability to cleave the HSV-2 genome: inherent potential for biosynthetic versus live recombinant microbicides

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dc.contributor.authorWayengera, Misaki
dc.contributor.authorKajumbula, Henry
dc.contributor.authorByarugaba, Wilson
dc.date.accessioned2021-12-12T18:49:12Z
dc.date.available2021-12-12T18:49:12Z
dc.date.issued2008
dc.description.abstractHerpes Simplex virus types 1 and 2 are enveloped viruses with a linear dsDNA genome of ~120–200 kb. Genital infection with HSV-2 has been denoted as a major risk factor for acquisition and transmission of HIV-1. Developing biomedical strategies for HSV-2 prevention is thus a central strategy in reducing global HIV-1 prevalence. This paper details the protocol for the isolation of restriction endonucleases (REases) with potent activity against the HSV-2 genome and models two biomedical interventions for preventing HSV-2.en_US
dc.identifier.citationWayengera, M., Kajumbula, H., & Byarugaba, W. (2008). Identification of restriction endonuclease with potential ability to cleave the HSV-2 genome: inherent potential for biosynthetic versus live recombinant microbicides. Theoretical Biology and Medical Modeling , 5 (1), 1-12. doi:10.1186/1742-4682-5-18en_US
dc.identifier.other10.1186/1742-4682-5-18
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/378
dc.language.isoenen_US
dc.publisherTheoretical Biology and Medical Modelingen_US
dc.subjectEndonucleaseen_US
dc.subjectHSV-2 genomeen_US
dc.subjectBiosyntheticen_US
dc.subjectMicrobicidesen_US
dc.titleIdentification of restriction endonuclease with potential ability to cleave the HSV-2 genome: inherent potential for biosynthetic versus live recombinant microbicidesen_US
dc.typeArticleen_US
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