Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
BMC infectious diseases
Abstract
Treatment for severe malaria must be prompt with effective parenteral antimalarial drugs for at least 24 h to achieve fast parasite clearance, and when the patient can tolerate oral therapy, treatment should be completed with effective artemisinin based combination therapy (ACT) for complete parasite clearance and to prevent recrudescence. We evaluated piperaquine concentration and malaria treatment outcomes among Ugandan children treated for severe malaria with intravenous artesunate (AS) or quinine (QN) plus dihydroartemisininpiperaquine (DP), in Tororo District Hospital in Eastern Uganda.
Description
Keywords
Piperaquine, Pharmacokinetics, Malaria, Children
Citation
Byakika-Kibwika, P., Ssenyonga, R., Lamorde, M., Blessborn, D., & Tarning, J. (2019). Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine. BMC infectious diseases, 19(1), 1-7. https://doi.org/10.1186/s12879-019-4647-2