Timing of onset of symptom for COVID-19 from publicly reported confirmed cases in Uganda
| dc.contributor.author | Riolexus Ario, Alex | |
| dc.contributor.author | Basuta Mirembe, Bernadette | |
| dc.contributor.author | Biribawa, Claire | |
| dc.contributor.author | Bulage, Lilian | |
| dc.contributor.author | Kadobera, Daniel | |
| dc.contributor.author | Wamala, Robert | |
| dc.date.accessioned | 2022-12-06T09:12:28Z | |
| dc.date.available | 2022-12-06T09:12:28Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | incubation period for COVID-19, 2-14 (average 5-6) days. Timing of onset of COVID-19 signs and symptoms amongst cases in Uganda is however not known. Methods: we utilized data on real-time reverse transcription polymerase chain reaction (RT-PCR) confirmed cases to investigate symptom onset timing, from 21st March to 4th September 2020. Since timing of COVID-19 symptom onset is highly likely to be an interval rather than a point estimate, we generated 3-tertile categories: 1st, 2nd and 3rd tertile denoting symptom presentation within 3, 4 to 6 and at least 7 days. We considered all signs and symptoms in the database and analysed using Chi-square test and multinomial logistic regression, controlling for age and sex. Results: we analysed a total of 420 symptomatic case-patients; 72.0% were males, median age of 33 years. Common symptoms were cough (47.6%), running nose (46.2%), fever (27.4%), headache (26.4%) and sore throat (20.5%). We utilized 293 cases with clinical symptom onset date recorded. Most of the patients, 37.5%, presented symptom within 3 days, 31.4% had symptoms in the 2nd and 31.4% in 3rd tertile, denoting 4 to 6 days and at least 7 days after exposure. Running nose (RRR=0.45, 95%CI: 0.24-0.84) and chest pain (RRR=0.64, 95%CI: 0.09-0.72) were more likely to occur in 3rd tertile than 1st or 2nd tertile. Cases aged ≥20 years were less likely to have symptoms in the 1st and 2nd tertile compared to ≤20 years (p<0.05). Conclusion: our study provides empirical evidence for epidemiological characterization of cases by signs and symptoms which complements current proposals for the length of active monitoring of persons exposed to SARS-CoV-2. | en_US |
| dc.identifier.citation | Alex Riolexus Ario et al. Timing of onset of symptom for COVID-19 from publicly reported confirmed cases in Uganda. Pan African Medical Journal. 2021;38(168). 10.11604/pamj.2021.38.168.27673 | en_US |
| dc.identifier.other | 10.11604/pamj.2021.38.168.27673 | |
| dc.identifier.uri | https://nru.uncst.go.ug/handle/123456789/5942 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pan African Medical Journal | en_US |
| dc.subject | Timing | en_US |
| dc.subject | Symptom | en_US |
| dc.subject | COVID-19 | en_US |
| dc.subject | Uganda | en_US |
| dc.title | Timing of onset of symptom for COVID-19 from publicly reported confirmed cases in Uganda | en_US |
| dc.type | Article | en_US |