Risk Assessment for the Implementation of Controlled Human Schistosoma Mansoni Infection Trials in Uganda

Simple item page
dc.contributor.authorKoopman, Jan Pieter
dc.contributor.authorEgesa, Moses
dc.contributor.authorWajja, Anne
dc.contributor.authorAdriko, Moses
dc.contributor.authorNassuuna, Jacent
dc.contributor.authorNkurunungi, Gyaviira
dc.contributor.authorDriciru, Emmanuella
dc.contributor.authorCose, Stephen
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorKabatereine, Narcis
dc.contributor.authorTukahebwa, Edridah
dc.contributor.authorElliott, Alison M.
dc.date.accessioned2023-06-26T16:57:45Z
dc.date.available2023-06-26T16:57:45Z
dc.date.issued2019
dc.description.abstractSchistosomiasis is a parasitic infection highly prevalent in sub-Saharan Africa, and a significant cause of morbidity; it is a priority for vaccine development. A controlled human infection model for Schistosoma mansoni (CHI-S) with potential to accelerate vaccine development has been developed among naïve volunteers in the Netherlands. Because responses both to infections and candidate vaccines are likely to differ between endemic and non-endemic settings, we propose to establish a CHI-S in Uganda where Schistosoma mansoni is endemic. As part of a “road-map” to this goal, we have undertaken a risk assessment. We identified risks related to importing of laboratory vector snails and schistosome strains from the Netherlands to Uganda; exposure to natural infection in endemic settings concurrently with CHI-S studies, and unfamiliarity of the community with the nature, risks and rationale for CHI. Mitigating strategies are proposed. With careful implementation of the latter, we believe that CHI-S can be implemented safely in Uganda. Our reflections are presented here to promote feedback and discussion.en_US
dc.identifier.citationKoopman, J. P., Egesa, M., Wajja, A., Adriko, M., Nassuuna, J., Nkurunungi, G., ... & Elliott, A. M. (2019). Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda. AAS open research, 2.https://doi.org/10.12688%2Faasopenres.12972.2en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8991
dc.language.isoenen_US
dc.publisherAAS open researchen_US
dc.subjectSchistosoma mansonien_US
dc.subjectControlled Human Infection Studiesen_US
dc.subjectRisk assessmenten_US
dc.titleRisk Assessment for the Implementation of Controlled Human Schistosoma Mansoni Infection Trials in Ugandaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda.pdf
Size:
315.25 KB
Format:
Adobe Portable Document Format
Description:
Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences