HIV-infected women on antiretroviral treatment have increased mortality during pregnant and postpartum periods

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dc.contributor.authorMatthews, Lynn T.
dc.contributor.authorKaida, Angela
dc.contributor.authorKanters, Steven
dc.contributor.authorByakwagamd, Helen
dc.contributor.authorMocello, A. Rain
dc.contributor.authorMuzoora, Conrad
dc.contributor.authorKembabazi, Annet
dc.contributor.authorHaberer, Jessica E.
dc.contributor.authorMartin, Jeffrey N.
dc.contributor.authorBangsberg, David R.
dc.contributor.authorHunt, Peter W.
dc.date.accessioned2022-01-31T12:29:09Z
dc.date.available2022-01-31T12:29:09Z
dc.date.issued2013
dc.description.abstractTo assess the impact of pregnancy on mortality among HIV-infected Ugandan women initiating ART. Prospective cohort study. HIV-infected women initiating ART in the Uganda AIDS Rural Treatment Outcomes study were assessed quarterly for self-reported pregnancy. The association between pregnancy and postpartum (‘pregnancy-related’) follow-up periods and mortality was assessed with Cox proportional hazards models adjusted for age, CD4 cell count, plasma HIV-1 RNA levels, and ART duration. Results: Three hundred and fifty-four women with median age 33 years (IQR: 27–37) and CD4 142 cells/ml (IQR: 82–213) were followed for a median of 4.0 years (IQR: 2.5–4.8) after ART initiation, with 3 and 7% loss-to-follow-up at years 1 and 5. One hundred and nine women experienced pregnancy. Five deaths occurred during pregnancy-related follow-up and 16 during nonpregnancy-related follow-up, for crude mortality rates during the first year after ART initiation of 12.57/100 PYs and 3.53/100 PYs (rate ratio 3.56, 95% CI: 0.97–11.07). In adjusted models, the impact of pregnancy related follow-up on mortality was highest at ART initiation (aHR: 21.48, 95% CI: 3.73–123.51), decreasing to 13.44 (95% CI 3.28–55.11) after 4 months, 8.28 (95% CI 2.38–28.88) after 8 months, 5.18 (95% CI: 1.36–19.71) after 1 year, and 1.25 (95% CI: 0.10–15.58) after 2 years on ART. Four of five maternal deaths occurred postpartum.en_US
dc.identifier.citationMatthews, L. T., Kaida, A., Kanters, S., Byakwaga, H., Mocello, A. R., Muzoora, C., ... & Hunt, P. W. (2013). HIV-infected women on antiretroviral treatment in Uganda have increased mortality during pregnant and postpartum periods. AIDS (London, England), 27(0 1), S105. DOI:10.1097/QAD.0000000000000040en_US
dc.identifier.other10.1097/QAD.0000000000000040
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1669
dc.language.isoenen_US
dc.publisherAIDS (London, England)en_US
dc.subjectAfricaen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectHIVen_US
dc.subjectImmune reconstitutionen_US
dc.subjectMaternal healthen_US
dc.subjectMaternal mortalityen_US
dc.subjectMortalityen_US
dc.subjectPostpartumen_US
dc.subjectPregnancyen_US
dc.subjectWomenen_US
dc.titleHIV-infected women on antiretroviral treatment have increased mortality during pregnant and postpartum periodsen_US
dc.typeArticleen_US
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