Genetic Diversity of Bundibugyo Ebolavirus from Uganda and the Democratic Republic of Congo
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Date
2021
Authors
Omara, Isaac Emmanuel
Kiwuwa-Muyingo, Sylvia
Balinandi, Stephen
Nyakarahuka, Luke
Kiconco, Jocelyn
Kayiwa, John Timothy
Mboowa, Gerald
Jjingo, Daudi
Lutwama, Julius J.
Journal Title
Journal ISSN
Volume Title
Publisher
bioRxiv
Abstract
The Ebolavirus is one of the deadliest viral pathogens which was first discovered in the year 1976
during two consecutive outbreaks in the Democratic Republic of Congo and Sudan. Six known
strains have been documented. The Bundibugyo Ebolavirus in particular first emerged in the year
2007 in Uganda. This outbreak was constituted with 116 human cases and 39 laboratory confirmed
deaths. After 5 years, it re-emerged and caused an epidemic for the first time in the Democratic
Republic of Congo in the year 2012 as reported by the WHO. Here, 36 human cases with 13
laboratory confirmed deaths were registered. Despite several research studies conducted in the past,
there is still scarcity of knowledge available on the genetic diversity of Bundibugyo Ebolavirus. We
undertook a research project to provide insights into the unique variants of Bundibugyo Ebolavirus
that circulated in the two epidemics that occurred in Uganda and the Democratic Republic of Congo
Description
Keywords
Bundibugyo, Ebolavirus, RT-PCR, DRC, RNA, Viral Hemorrhagic Fever
Citation
Omara, I. E., Muyingo, S. K., Balinandi, S., Nyakarahuka, L., Kiconco, J., Kayiwa, J. T., ... & Lutwama, J. J. (2021). Genetic Diversity of Bundibugyo Ebolavirus from Uganda and the Democratic Republic of Congo. bioRxiv. https://doi.org/10.1101/2021.10.18.464898