Descriptive epidemiology of rubella disease and associated virus strains in Uganda

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dc.contributor.authorTushabe, Phionah
dc.contributor.authorBwogi, Josephine
dc.contributor.authorAbernathy, Emily
dc.contributor.authorBirungi, Molly
dc.contributor.authorEliku, James P.
dc.contributor.authorSeguya, Ronald
dc.contributor.authorBukenya, Henry
dc.contributor.authorNamuwulya, Prossy
dc.contributor.authorKakooza, Proscovia
dc.contributor.authorSuppiah, Suganthi
dc.contributor.authorKabaliisa, Theopista
dc.contributor.authorTibanagwa, Mayi
dc.contributor.authorAmpaire, Immaculate
dc.contributor.authorKisakye, Annet
dc.contributor.authorBakainaga, Andrew
dc.contributor.authorByabamazima, Charles R.
dc.contributor.authorIcenogle, Joseph P.
dc.contributor.authorBakamutumaho, Barnabas
dc.date.accessioned2022-08-05T11:38:20Z
dc.date.available2022-08-05T11:38:20Z
dc.date.issued2020
dc.description.abstractRubella virus causes a mild disease; however, infection during the first trimester of pregnancy may lead to congenital rubella syndrome (CRS) in over 80% of affected pregnancies. Vaccination is recommended and has been shown to effectively reduce CRS incidence. Uganda plans to introduce routine rubella vaccination in 2019. The World Health Organization recommends assessing the disease burden and obtaining the baseline molecular virological data before vaccine introduction. Sera collected during case‐based measles surveillance from January 2005 to July 2018 were tested for rubella immunoglobulin M (IgM) antibodies. Sera from confirmed rubella outbreaks from January 2012 to August 2017 were screened using real‐time reverse‐transcription polymerase chain reaction (RT‐PCR); for positive samples, a region within the E1 glycoprotein coding region was amplified and sequenced. Of the 23 196 suspected measles cases serologically tested in parallel for measles and rubella, 5334 (23%) were rubella IgM‐positive of which 2710 (50.8%) cases were females with 2609 (96.3%) below 15 years of age. Rubella IgM‐positive cases were distributed throughout the country and the highest number was detected in April, August, and November. Eighteen (18%) of the 100 sera screened were real‐time RTPCR‐ positive of which eight (44.4%) were successfully sequenced and genotypes 1G and 2B were identified. This study reports on the seroprevalence and molecular epidemiology of rubella. Increased knowledge of former and current rubella viruses circulating in Uganda will enhance efforts to monitor the impact of vaccination as Uganda moves toward control and elimination of rubella and CRS.en_US
dc.identifier.citationTushabe, P., Bwogi, J., Abernathy, E., Birungi, M., Eliku, J. P., Seguya, R., ... & Bakamutumaho, B. (2020). Descriptive epidemiology of rubella disease and associated virus strains in Uganda. Journal of Medical Virology, 92(3), 279-287. DOI: 10.1002/jmv.25604en_US
dc.identifier.other10.1002/jmv.25604
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4256
dc.language.isoenen_US
dc.publisherJournal of Medical Virologyen_US
dc.subjectCongenital rubella syndromeen_US
dc.subjectGenotypeen_US
dc.subjectVaccinationen_US
dc.titleDescriptive epidemiology of rubella disease and associated virus strains in Ugandaen_US
dc.typeArticleen_US
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