Trends of notification rates and treatment outcomes of tuberculosis cases with and without HIV co-infection in eight rural districts of Uganda (2015 – 2019)

Simple item page
dc.contributor.authorBaluku, Joseph Baruch
dc.contributor.authorNanyonjo, Resty
dc.contributor.authorAyo, Jolly
dc.contributor.authorObwalatum, Jehu Eleazer
dc.contributor.authorNakaweesi, Jane
dc.contributor.authorSenyimba, Catherine
dc.contributor.authorLukoye, Deus
dc.contributor.authorLubwama, Joseph
dc.contributor.authorWard, Jennifer
dc.contributor.authorMukasa, Barbara
dc.date.accessioned2023-11-21T11:56:12Z
dc.date.available2023-11-21T11:56:12Z
dc.date.issued2022-04
dc.description.abstractAbstract Background The End TB Strategy aims to reduce new tuberculosis (TB) cases by 90% and TB-related deaths by 95% between 2015 – 2035. We determined the trend of case notification rates (CNRs) and treatment outcomes of TB cases with and without HIV co-infection in rural Uganda to provide an interim evaluation of progress towards this global target in rural settings. Methods We extracted retrospective programmatic data on notified TB cases and treatment outcomes from 2015 – 2019 for eight districts in rural Uganda from the District Health Information System 2. We estimated CNRs as the number of TB cases per 100,000 population. Treatment success rate (TSR) was calculated as the sum of TB cure and treatment completion for each year. Trends were estimated using the Mann–Kendall test. Results A total of 11,804 TB cases, of which 5,811 (49.2%) were HIV co-infected, were notified. The overall TB CNR increased by 3.7-fold from 37.7 to 141.3 cases per 100,000 population in 2015 and 2019 respectively. The increment was observed among people with HIV (from 204.7 to 730.2 per 100,000, p = 0.028) and HIV-uninfected individuals (from 19.9 to 78.7 per 100,000, p = 0.028). There was a decline in the TSR among HIV-negative TB cases from 82.1% in 2015 to 63.9% in 2019 (p = 0.086). Conversely, there was an increase in the TSR among HIV co-infected TB cases (from 69.9% to 81.9%, p = 0.807). Conclusion The CNR increased among people with and without HIV while the TSR reduced among HIV-negative TB cases. There is need to refocus programs to address barriers to treatment success among HIV-negative TB cases.en_US
dc.identifier.citationBaluku, Joseph Baruch, Resty Nanyonjo, Jolly Ayo, et al. 'Trends of Notification Rates and Treatment Outcomes of Tuberculosis Cases with and without HIV Co-Infection in Eight Rural Districts of Uganda (2015 - 2019)', BMC Public Health, vol. 22/no. 1, (2022), pp. 651-651.en_US
dc.identifier.issnISSN 1471-2458
dc.identifier.issnEISSN 1471-2458
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9343
dc.language.isoenen_US
dc.publisherBioMed Central Ltden_US
dc.subjectCase notification rate; Tuberculosis; Rural; Uganda; HIV; TB/HIVen_US
dc.titleTrends of notification rates and treatment outcomes of tuberculosis cases with and without HIV co-infection in eight rural districts of Uganda (2015 – 2019)en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s12889-022-13111-1.pdf
Size:
1004.09 KB
Format:
Adobe Portable Document Format
Description:
Journal Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences