Comparison of HIV-1 Mother-to-Child Transmission After Single-Dose Nevirapine Prophylaxis Among African Women With Subtypes A, C, and D

Simple item page
dc.contributor.authorEshleman, Susan
dc.contributor.authorChurch, Jessica
dc.contributor.authorGuay, Laura A.
dc.contributor.authorMwatha, Anthony
dc.contributor.authorFiscus, Susan A.
dc.contributor.authorMmiro, Francis
dc.contributor.authorMusoke, Philippa
dc.contributor.authorKumwenda, Newton
dc.contributor.authorJackson, J. Brooks
dc.contributor.authorTaha, Taha E.
dc.contributor.authorHoover, Donald R.
dc.date.accessioned2022-02-01T10:23:14Z
dc.date.available2022-02-01T10:23:14Z
dc.date.issued2006
dc.description.abstractThe HIVNET 012 trial in Uganda showed that mother-to-child transmission (MTCT) of HIV-1 can be prevented by providing pregnant women and their infants with a single dose (SD) of the antiretroviral drug, nevirapine (NVP).1,2 Safety and efficacy of 1- or 2-dose NVP prophylaxis for prevention of MTCT have been documented in other studies. We have shown that NVP resistance emerges in some women after SD NVP prophylaxis3 and that the portion of women with NVP resistance is influenced by HIV-1 subtype.4 At 6 to 8 weeks after SD NVP, NVP resistance was more common in women with subtype C (69.2%) than in women with subtype D (36.1%, P < 0.0001) or subtype A (19.4%, P < 0.0001).4 Selection of NVP-resistant HIV-1 variants in women after NVP dosing could theoretically lower the efficacy of NVP prophylaxis for prevention of HIV transmission by breast-feeding in the first few weeks after birth. In the HIVNET 012 trial, most women were infected with HIV-1 subtype A or D. Risk of MTCT was slightly (but not statistically) higher in women with subtype D.5 In this report, we combined data from the HIVNET 012 and NVAZ trials6 to compare the risk of MTCT in women with subtype C to the risk of MTCT in women with subtypes A and D in the setting of SD NVP prophylaxis.en_US
dc.identifier.citationEshleman, S. H., Church, J. D., Chen, S., Guay, L. A., Mwatha, A., Fiscus, S. A., ... & Hoover, D. R. (2006). Comparison of HIV-1 mother-to-child transmission after single-dose nevirapine prophylaxis among African women with subtypes A, C, and D. JAIDS Journal of Acquired Immune Deficiency Syndromes, 42(4), 518-521.doi: 10.1097/01.qai.0000221676.22069.b8en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1727
dc.language.isoenen_US
dc.publisherJAIDS Journal of Acquired Immune Deficiency Syndromesen_US
dc.titleComparison of HIV-1 Mother-to-Child Transmission After Single-Dose Nevirapine Prophylaxis Among African Women With Subtypes A, C, and Den_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Comparison of HIV-1.pdf
Size:
221.32 KB
Format:
Adobe Portable Document Format
Description:
Comparison of HIV-1 Mother-to-Child Transmission After Single-Dose Nevirapine Prophylaxis Among African Women With Subtypes A, C, and D
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences