Establishing a controlled hookworm human infection (CHHI) model for Africa: A report from the stakeholders meeting held in Lambaréné, Gabon, November 10–11, 2019

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dc.contributor.authorAlabi, Ayodele
dc.contributor.authorMengome, Christine Ndong
dc.contributor.authorEgesa, Moses
dc.contributor.authorDriciru, Emmanuella
dc.contributor.authorWammes, Linda J.
dc.contributor.authorAdegnika, Ayola Akim
dc.contributor.authorAgnandji, Selidji Todagbe
dc.date.accessioned2023-06-22T19:55:05Z
dc.date.available2023-06-22T19:55:05Z
dc.date.issued2021
dc.description.abstractHookworm is a major contributor to worldwide disease burden with over 230 million people infected. It has been identified as one of the Neglected Tropical Diseases that can be controlled and even eliminated through mass drug administration and other effective interventions. Mathematical models have shown that hookworm can only be eliminated via a vaccine. Controlled Hookworm Human Infection (CHHI) models can facilitate rapid development of vaccines and drugs. As a first step towards the establishment of CHHI in Africa, we held a stakeholders meeting in Lamberene, Gabon from 10 to 11 November 2019. Discussions revolved around the roles of the different regulatory institutions concerned; the need to strengthen existing regulatory capacity and the role of legislation; creating Gabon-specific ethical guidelines to govern Controlled Human Infection (CHI) studies; development of a study protocol; consideration of cultural and social peculiarities; the need for regular joint review meetings between interested parties throughout the process of protocol implementation; and participant compensation. Moreover, operational considerations concerning the introduction of CHHI in Gabon include the use of the local strain of hookworm for the challenge infections, capacity building for the local production of challenge material, and the establishment of adequate quality assurance procedures. The workshop addressed several of the anticipated hurdles to the successful implementation of CHHI in Gabon. It is our aim that this report will stimulate interest in the implementation of this model in the sub-Saharan African setting.en_US
dc.identifier.citationAlabi, A., Hussain, M., Hoogerwerf, M. A., Mengome, C. N., Egesa, M., Driciru, E., ... & Agnandji, S. T. (2021). Establishing a controlled hookworm human infection (CHHI) model for Africa: A report from the stakeholders meeting held in Lambaréné, Gabon, November 10–11, 2019. Archives of Public Health, 79(1), 1-8.https://doi.org/10.1186/s13690-021-00650-zen_US
dc.identifier.issn2049-3258
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8977
dc.language.isoenen_US
dc.publisherArchives of Public Healthen_US
dc.subjectVaccine developmenten_US
dc.subjectControlled human infection modelen_US
dc.subjectNecator americanusen_US
dc.titleEstablishing a controlled hookworm human infection (CHHI) model for Africa: A report from the stakeholders meeting held in Lambaréné, Gabon, November 10–11, 2019en_US
dc.typeArticleen_US
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