Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome

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dc.contributor.authorFoÈger, Kathrin
dc.contributor.authorGora-Stahlberg, Gina
dc.contributor.authorSejvar, James
dc.contributor.authorOvuga, Emilio
dc.contributor.authorilek-Aall, Louise J
dc.contributor.authorSchmutzhard, Erich
dc.contributor.authorKaiser, Christoph
dc.contributor.authorWinkler, Andrea S.
dc.date.accessioned2022-08-27T04:49:19Z
dc.date.available2022-08-27T04:49:19Z
dc.date.issued2017
dc.description.abstractNakalanga syndrome is a condition that was described in Uganda and various other African countries decades ago. Its features include growth retardation, physical deformities, endocrine dysfunction, mental impairment, and epilepsy, amongst others. Its cause remains obscure. Nodding syndrome is a neurological disorder with some features in common with Nakalanga syndrome, which has been described mainly in Uganda, South Sudan, and Tanzania. It has been considered an encephalopathy affecting children who, besides head nodding attacks, can also present with stunted growth, delayed puberty, and mental impairment, amongst other symptoms. Despite active research over the last years on the pathogenesis of Nodding syndrome, to date, no convincing single cause of Nodding syndrome has been reported. In this review, by means of a thorough literature search, we compare features of both disorders. We conclude that Nakalanga and Nodding syndromes are closely related and may represent the same condition. Our findings may provide new directions in research on the cause underlying this neurological disorder.en_US
dc.identifier.citationFoÈger K, Gora-Stahlberg G, Sejvar J, Ovuga E, Jilek-Aall L, Schmutzhard E, et al. (2017) Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome. PLoS Negl Trop Dis 11(2): e0005201. doi:10.1371/journal. pntd.0005201en_US
dc.identifier.other10.1371/journal. pntd.0005201
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4444
dc.language.isoenen_US
dc.publisherPLOS Neglected Tropical Diseasesen_US
dc.subjectNakalanga Syndromeen_US
dc.subjectClinical Characteristicsen_US
dc.subjectPotential Causesen_US
dc.subjectNodding Syndromeen_US
dc.titleNakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndromeen_US
dc.typeArticleen_US
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