Implications of Microfauna-Host Interactions for Trypanosome Transmission Dynamics in Glossina fuscipes fuscipes in Uganda
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Applied and Environmental Microbiology
Abstract
Tsetse flies (Diptera: Glossinidae) are vectors for African trypanosomes (Euglenozoa: kinetoplastida), protozoan parasites that
cause African trypanosomiasis in humans (HAT) and nagana in livestock. In addition to trypanosomes, two symbiotic bacteria
(Wigglesworthia glossinidia and Sodalis glossinidius) and two parasitic microbes, Wolbachia and a salivary gland hypertrophy
virus (SGHV), have been described in tsetse. Here we determined the prevalence of and coinfection dynamics between Wolbachia,
trypanosomes, and SGHV in Glossina fuscipes fuscipes in Uganda over a large geographical scale spanning the range of host
genetic and spatial diversity. Using a multivariate analysis approach, we uncovered complex coinfection dynamics between the
pathogens and statistically significant associations between host genetic groups and pathogen prevalence. It is important to note
that these coinfection dynamics and associations with the host were not apparent by univariate analysis. These associations between
host genotype and pathogen are particularly evident for Wolbachia and SGHV where host groups are inversely correlated
for Wolbachia and SGHV prevalence. On the other hand, trypanosome infection prevalence is more complex and covaries with
the presence of the other two pathogens, highlighting the importance of examining multiple pathogens simultaneously before
making generalizations about infection and spatial patterns. It is imperative to note that these novel findings would have been
missed if we had employed the standard univariate analysis used in previous studies. Our results are discussed in the context of
disease epidemiology and vector control.
Description
Keywords
Microfauna-Host Interactions, Trypanosome Transmission Dynamics, Glossina fuscipes fuscipes, Uganda
Citation
Alam, U., Hyseni, C., Symula, RE, Brelsfoard, C., Wu, Y., Kruglov, O., ... & Aksoy, S. (2012). Implications of microfauna-host interactions for trypanosome transmission dynamics in Glossina fuscipes fuscipes in Uganda. Applied and Environmental Microbiology , 78 (13), 4627-4637. doi:10.1128/AEM.00806-12