Seroprevalence of brucellosis and risk factors associated with its seropositivity in cattle, goats and humans in Iganga District, Uganda

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dc.contributor.authorNguna, Joyce
dc.contributor.authorDione, Michel
dc.contributor.authorApamaku, Micheal
dc.contributor.authorMajalija, Samuel
dc.contributor.authorRwabita Mugizi, Denis
dc.contributor.authorOdoch, Terence
dc.contributor.authorKato, Charles Drago
dc.contributor.authorTumwine, Gabriel
dc.contributor.authorKabaasa, John David
dc.contributor.authorCurtis, Kellie
dc.contributor.authorGraham, Michael
dc.contributor.authorEjobi, Francis
dc.contributor.authorGraham, Thomas
dc.date.accessioned2022-02-13T19:01:15Z
dc.date.available2022-02-13T19:01:15Z
dc.date.issued2019
dc.description.abstractThe burden of brucellosis among smallholder farmers is poorly-documented in Uganda. The disease burden is likely to be high, given the high levels of endemicity, lots of exposures and due to lack of control measures. In order to designate appropriate control measures, the magnitude and risk factors for brucellosis need to be known. We established the burden of and risk factors for Brucella seropositivity in cattle, goats, and humans in Iganga district, eastern Uganda. Methods: a cross-sectional study was conducted in in Kigulamo Parish, Iganga District. We enrolled 226 households and administered a structured questionnaire to heads of households to capture data on socio-demographic characteristics, human brucellosis-related risk factors, and livestock farming practices. Human, cattle, and goat blood samples were collected and tested serologically using commercial indirect-ELISA kits manufactured by USDA, USA. Results: of 451 human blood samples, 20 (4.4%) were positive. Among 345 cattle blood samples, 4 (1.2%) were positive and among 351 goat blood samples, one (0.3%) was positive. Persons who reported consuming locally-made dairy products had 4 times higher odds of Brucella seropositivity (OR = 4.0, CI = 1.14-14.03, p = 0.031) than those who did not. None of the risk factors we asked about were significantly associated with seropositivity in cattle and goats. Conclusion: the seroprevalence of brucellosis in humans in smallholder households in Kigulamo was relatively low and associated with consumption of locally made dairy products. No ri sk factors were significantly associated with seropositivity in livestock, likely due to the small number of seropositive animals. We recommend a One Health approach to control brucellosis simultaneously in animals and humans needed to sustainably reduce the burden of brucellosis in Uganda and beyond.en_US
dc.identifier.citationNguna, J., Dione, M., Apamaku, M., Majalija, S., Mugizi, D. R., Odoch, T., ... & Graham, T. (2019). Seroprevalence of brucellosis and risk factors associated with its seropositivity in cattle, goats and humans in Iganga District, Uganda. The Pan African Medical Journal, 33. doi:10.11604/pamj.2019.33.99.16960en_US
dc.identifier.other10.11604/pamj.2019.33.99.16960
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2089
dc.language.isoenen_US
dc.publisherThe Pan African Medical Journalen_US
dc.subjectBrucellosisen_US
dc.subjectHumanen_US
dc.subjectAnimalsen_US
dc.subjectSeroprevalenceen_US
dc.subjectRisk factorsen_US
dc.subjectGlobal Health Securityen_US
dc.subjectUgandaen_US
dc.titleSeroprevalence of brucellosis and risk factors associated with its seropositivity in cattle, goats and humans in Iganga District, Ugandaen_US
dc.typeArticleen_US
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