Trends and distribution of Vibrio cholerae isolates at the National Microbiology Reference Laboratory, Ministry of Health, Uganda, 2014 –2023

Simple item page
dc.contributor.authorBaliruno, Leah Naluwagga
dc.contributor.authorNamusoosa, Rita
dc.contributor.authorGidudu, Samuel
dc.contributor.authorOkello, Paul Edward
dc.contributor.authorNakigozi, Harriet
dc.contributor.authorOkiria, Chris
dc.contributor.authorSsewanyana, Isaac
dc.contributor.authorNabadda, Suzan
dc.contributor.authorNajjuka, Grace
dc.contributor.authorArio, Alex Riolexus
dc.date.accessioned2025-04-05T16:35:28Z
dc.date.available2025-04-05T16:35:28Z
dc.date.issued2018
dc.description.abstractBackground: As per the World Health Organization, countries including Uganda are to end cholera by 2030 through prevention and treatment. This achievement can be hindered due to rapid changes in antimicrobial response patterns and serotype among other factors. We described confirmed cholera cases by person, place, time, serotype, antimicrobial resistance, and multi-antimicrobial-resistant phenotype patterns, Uganda, 2014–2023. Methods: We conducted a descriptive study using the 2014 – 2023 data on confirmed cholera cases abstracted from the National Microbiology Reference Laboratory (NMRL) register. We described the cases by age group, sex, district, serotype, reporting period, antimicrobial resistance (resistant and intermediate)(rates), and multi-antimicrobialresistant phenotype patterns. We described the confirmed cases and the antimicrobial resistance patterns over time. Mann-Kendall tests for trends were used to test the significance of AMR trends. Results: We identified 489 confirmed cholera cases between January 2014 to December 2023 whose V. cholerae isolates were referred by 35 districts in Uganda. The majority of the identified confirmed cholera cases were male (239, 49%), aged 21- 40 years (170, 38%), had V. cholerae 01 Ogawa (256, 52%) and were from Kampala District (138, 28%). We observed a gradual decline in confirmed cholera cases over time with peaks in 2015, 2018 and 2023. Vibro cholerae 01 ogawa was observed to dominate throughout the period. We observed consistent resistance by V. cholerae to 6 antimicrobials from 2014 to 2023. 194 (39.7%) isolates showed multiple antimicrobialresistant with 90 (18.6%) resistant to more than one class of antimicrobials. Conclusion: We observed males, persons aged 21-40 years, and Kampala District as being most affected with cholera in Uganda with peaks in 2015, 2018, and 2023 and Vibro cholerae 01 Ogawa as the predominate serotype. Consistent antimicrobial resistance was exhibited over time between 2014 and 2023. Intensifying cholera disease prevention by the Ministry of Health targeting males, persons aged 21-40 years, and Kampala District is critical. Routine antimicrobial surveillance to guide informed antimicrobial use and prevent the spread of AMR, especially during cholera outbreaks is important.
dc.identifier.citationBaliruno, L. N., Namusoosa, R., Gidudu, S., Okello, P. E., Nakigozi, H., Okiria, C., ... & Ario, A. R. Trends and distribution of Vibrio cholerae isolates at the National Microbiology Reference Laboratory, Ministry of Health, Uganda, 2014–2023. Age, 2(18), 3-7.
dc.identifier.urihttps://uniph.go.ug/trends-and-distribution-of-vibrio-cholerae-isolates-at-the-national-microbiology-reference-laboratory-ministry-of-health-uganda-2014-2023/
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/10385
dc.language.isoen
dc.publisherUganda Public Health
dc.relation.ispartofseries4; 9
dc.titleTrends and distribution of Vibrio cholerae isolates at the National Microbiology Reference Laboratory, Ministry of Health, Uganda, 2014 –2023
dc.typeOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Trends and distribution of Vibrio cholerae isolates at.pdf
Size:
460.03 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences