Comparison of fasting plasma glucose and haemoglobin A1c point-of-care tests in screening for diabetes and abnormal glucose regulation in a rural low income setting

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dc.contributor.authorMayega, Roy William
dc.contributor.authorGuwatudde, David
dc.contributor.authorMakumbi, Fredrick Edward
dc.contributor.authorNakwagala, Frederick Nelson
dc.contributor.authorPeterson, Stefan
dc.contributor.authorTomson, Goran
dc.contributor.authorOstenson, Claes-Goran
dc.date.accessioned2022-02-05T11:51:39Z
dc.date.available2022-02-05T11:51:39Z
dc.date.issued2014
dc.description.abstractGlycated haemoglobin (HbA1C) has been suggested to replace glucose tests in identifying diabetes and pre-diabetes. We assessed agreement between fasting plasma glucose (FPG) and HbA1C rapid tests in classifying abnormal glucose regulation (AGR), and their utility for preventive screening in rural Africa. Methods: A population-based survey of 795 people aged 35–60 years was conducted in a mainly rural district in Uganda. FPG was measured using On-Call1 Plus glucometers, and classified using World Health Organization (WHO) and American Diabetes Association (ADA) criteria. HbA1C was measured using A1cNow1 kits and classified using ADA criteria. Body mass index and blood pressure were measured. Percentage agreement between the two tests was computed. Results: Using HbA1C, 11.3% of participants had diabetes compared with 4.8% for FPG. Prevalence of HbA1C-defined pre-diabetes (26.4%) was 1.2 times and 2.5 times higher than FPG-defined pre-diabetes using ADA (21.8%) and WHO (10.1%) criteria, respectively. With FPG as the reference, agreement between FPG and HbA1C in classifying diabetes status was moderate (Kappa = 22.9; Area Under the Curve (AUC) = 75%), while that for AGR was low (Kappa = 11.0; AUC = 59%). However, agreement was high (over 90%) among negative tests and among participants with risk factors for type 2 diabetes (obesity, overweight or hypertension). HbA1C had more procedural challenges than FPG.en_US
dc.identifier.citationMayega, R. W., Guwatudde, D., Makumbi, F. E., Nakwagala, F. N., Peterson, S., Tomson, G., & Östenson, C. G. (2014). Comparison of fasting plasma glucose and haemoglobin A1c point-of-care tests in screening for diabetes and abnormal glucose regulation in a rural low income setting. Diabetes Research and Clinical Practice, 104(1), 112-120. http://dx.doi.org/10.1016/j.diabres.2013.12.030en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.diabres.2013.12.030
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1942
dc.language.isoenen_US
dc.publisherDiabetes Research and Clinical Practiceen_US
dc.subjectDiabetesen_US
dc.subjectAbnormal glucose regulationen_US
dc.subjectEarly detectionen_US
dc.subjectFasting plasma glucoseen_US
dc.subjectHaemoglobin A1Cen_US
dc.subjectPercentage agreementen_US
dc.titleComparison of fasting plasma glucose and haemoglobin A1c point-of-care tests in screening for diabetes and abnormal glucose regulation in a rural low income settingen_US
dc.typeArticleen_US
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