Catatonia in Ugandan Children with NoddingSyndrome andEffects of Treatment with Lorazepam: a pilot study

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dc.contributor.authorKakooza‑Mwesige, Angelina
dc.contributor.authorDhossche, Dirk M.
dc.contributor.authorIdro, Richard
dc.contributor.authorAkena, Dickens
dc.contributor.authorNalugya, Joyce
dc.contributor.authorOpar, Benard T.
dc.date.accessioned2022-06-07T11:31:16Z
dc.date.available2022-06-07T11:31:16Z
dc.date.issued2015
dc.description.abstractNodding syndrome (NS) is a severe neuropsychiatric syndrome of an unknown etiology affecting children and adolescents mostly in Eastern Africa. Symptoms of NS and catatonia seem to overlap. We investigated the presence and types of catatonic symptoms in NS and their response to one or two doses of lorazepam, the first-line treatment for catatonia.A cross-sectional descriptive study with systematic assessment of catatonia in 33 patients with NS using a modified version of the Bush Francis Catatonia Rating Scale. Sixteen patients met criteria for catatonia and were observed in an open and uncontrolled study to examine the effects of one or two doses of lorazepam in them.Sixteen of 33 patients with NS had an average of 5 catatonia symptoms and met criteria for catatonia. The highest scores were found for mutism, staring, poor eating/drinking, stupor, and grimacing. Excitement, rigidity, negativism and impulsivity had lower scores. None of the children had echolalia or echopraxia. In 6 children, there was a reduction of more than 50 % in catatonia ratings, representing a positive response to lorazepam. Three out of six children whose catatonia ratings did not change after the first dose, responded after administration of a second double dose. There were no unusual or critical side-effects. About half of a selected sample of children with NS met criteria for catatonia. Catatonia scores decreased in most patients after one or two doses of lorazepam. Larger, longer, and controlled studies are warranted to assess the prevalence of catatonia in NS and to assess the use of lorazepam in NS through its effects on catatonia.en_US
dc.identifier.citationKakooza-Mwesige, A., Dhossche, D. M., Idro, R., Akena, D., Nalugya, J., & Opar, B. T. (2015). Catatonia in Ugandan children with nodding syndrome and effects of treatment with lorazepam: a pilot study. BMC research notes, 8(1), 1-11.https://doi.org/10.1186/s13104-015-1805-5en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3811
dc.language.isoenen_US
dc.publisherBMC research notesen_US
dc.titleCatatonia in Ugandan Children with NoddingSyndrome andEffects of Treatment with Lorazepam: a pilot studyen_US
dc.typeArticleen_US
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