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dc.contributor.authorIdro, Richard
dc.contributor.authorOpar, Bernard
dc.contributor.authorWamala, Joseph
dc.contributor.authorAbbo, Catherine
dc.contributor.authorOnzivua, Sylvester
dc.contributor.authorMwaka, Deogratius Amos
dc.contributor.authorKakooza-Mwesige, Angelina
dc.contributor.authorMbonye, Anthony
dc.contributor.authorAceng, Jane R.
dc.date.accessioned2022-06-01T18:54:08Z
dc.date.available2022-06-01T18:54:08Z
dc.date.issued2016
dc.identifier.citationIdro, R., Opar, B., Wamala, J., Abbo, C., Onzivua, S., Mwaka, D. A., ... & Aceng, J. R. (2016). Is nodding syndrome an Onchocerca volvulus-induced neuroinflammatory disorder? Uganda's story of research in understanding the disease. International Journal of Infectious Diseases, 45, 112-117. https://doi.org/10.1016/j.ijid.2016.03.002en_US
dc.identifier.issn1201-9712
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3646
dc.description.abstractNodding syndrome is a devastating neurological disorder, mostly affecting children in eastern Africa. An estimated 10 000 children are affected. Uganda, one of the most affected countries, set out to systematically investigate the disease and develop interventions for it. On December 21, 2015, the Ministry of Health held a meeting with community leaders from the affected areas to disseminate the results of the investigations made to date. This article summarizes the presentation and shares the story of studies into this peculiar disease. It also shares the results of preliminary studies on its pathogenesis and puts into perspective an upcoming treatment intervention. Clinical and electrophysiological studies have demonstrated nodding syndrome to be a complex epilepsy disorder. A definitive aetiological agent has not been established, but in agreement with other affected countries, a consistent epidemiological association has been demonstrated with infection by Onchocerca volvulus. Preliminary studies of its pathogenesis suggest that nodding syndrome may be a neuroinflammatory disorder, possibly induced by antibodies to O. volvulus cross-reacting with neuron proteins. Histological examination of post-mortem brains has shown some yet to be characterized polarizable material in the majority of specimens. Studies to confirm these observations and a clinical trial are planned for 2016.en_US
dc.language.isoenen_US
dc.publisherInternational Journal of Infectious Diseasesen_US
dc.subjectNodding syndrome, aetiology, O. volvulus, pathogenesis, treatmenten_US
dc.titleIs nodding syndrome an Onchocerca volvulus induced neuro-inflammatory disorder? Uganda's story of research in understanding the diseaseen_US
dc.typeArticleen_US


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