Show simple item record

dc.contributor.authorBbosa, Godfrey S.
dc.contributor.authorKyegombe, David B.
dc.contributor.authorAnokbonggo, William W.
dc.contributor.authorLubega, Aloysius
dc.contributor.authorMugisha, Apollo
dc.contributor.authorOgwal-Okeng, Jasper
dc.date.accessioned2022-05-02T22:19:25Z
dc.date.available2022-05-02T22:19:25Z
dc.date.issued2014
dc.identifier.citationBbosa, G. S., Kyegombe, D. B., Anokbonggo, W. W., Lubega, A., Mugisha, A., & Ogwal-Okeng, J. (2014). Chronic alcohol consumption affects serum enzymes levels in the HIV-infected patients on Stavudine (d4T)/lamivudine (3TC)/Nevirapine (NVP) treatment regimen. Pharmacology & Pharmacy, 2014. http://dx.doi.org/10.4236/pp.2014.52025en_US
dc.identifier.urihttp://dx.doi.org/10.4236/pp.2014.52025
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3172
dc.description.abstractChronic alcohol use is a common problem globally among the HIV-infected patients on ARV treatment regimens, leading to severe liver damage and increase in serum enzymes. The study determined effect of chronic alcohol intake on serum enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyl transferase (GGT)) in HIV-infected patients on d4T/3TC/NVP treatment regimen in Uganda using the WHO alcohol use disorders’ identification test (AUDIT) tool and chronic alcohol use biomarkers (ALT, AST, GGT, AST/ALT ≥ 2.0 and mean corpuscular volume (MCV)). A case control study using repeated measure design with serial measurements model was used. Alcohol use biomarkers were used to standardize the gender differences in alcohol use. A total of 41 patients (21 alcohol group and 20 control group) were followed up for 9 months with blood sampling done at 3 month intervals. The serum enzymes’ levels were determined by using the Cobas In-tergra 400 Plus analyzer system. The mean GGT levels were higher in chronic alcohol use group as compared to control group in both groups. The levels were above reference ranges during 6 month and three times higher during 9-month follow-up period for both chronic alcohol use self reporting WHO AUDIT tool and biomarkers’ groups. Generally, the mean AST, ALT and AST/ALT levels were slightly higher in alcohol use group as com-pared to control group and were slightly higher in both groups as compared to reference ranges during the 9 month follow-up period. Chronic alcohol consumption by HIV-infected patients on d4T/3TC/NVP drug regimen increased GGT and AST/ALT serum enzyme levels and hence was used as chronic alcohol use biomarkers.en_US
dc.language.isoenen_US
dc.publisherPharmacology & Pharmacyen_US
dc.subjectChronic Ethanol Useen_US
dc.subjectSerum Enzymesen_US
dc.subjectHIV-Infected Patientsen_US
dc.subjectAntiretroviral (ARVs) Drugsen_US
dc.titleChronic Alcohol Consumption Affects Serum Enzymes Levels in the HIV-Infected Patients on Stavudine (d4T)/Lamivudine (3TC)/Nevirapine (NVP) Treatment Regimenen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record