The Challenge of HIV-1 Antiretroviral Resistance in Africa in the Era of HAART
Easterbrook, Philippa J.
Reynolds, Steven J.
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Antiretroviral therapy programs in Africa are currently providing treatment for almost two million people. The long-term success of large scale antiretroviral therapy programs in sub-Saharan Africa remains uncertain because of the limited information currently available on rates of virologic failure and selection for drug-resistant variants in the different HIV subtypes. This article provides a comprehensive review of the published literature on the prevalence of primary and secondary HIV drug resistance with different subtypes and in various settings across sub-Saharan Africa.
- Medical and Health Sciences