Steady-state pharmacokinetics of rilpivirine under different meal conditions in HIV-1-infected Ugandan adults

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Date
2015Author
Lamorde, Mohammed
Walimbwa, Stephen
Byakika-Kibwika, Pauline
Katwere, Michael
Mukisa, Lillian
Sempa, Joseph B.
Else, Laura
Back, David J.
Khoo, Saye H.
Merry, Concepta
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Over 24 million people are living with HIV in sub-Saharan Africa, the region that also experiences the highest prevalence of food insecurity. ART is the cornerstone for management of HIV, but few treatment options are available in African countries. The
WHO recommends that first-line antiretroviral regimens should include one of two NNRTIs, either efavirenz or nevirapine. Although these drugs are efficacious, some patients may experience treatment-limiting toxicities, drug resistance or drug interactions with these agents; hence the need for more treatment options.
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