Browsing by Author "Wosu, Adaeze C."

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    An assessment of non-communicable disease mortality among adults in Eastern Uganda, 2010–2016
    (Plos one, 2021) Natukwatsa, Davis; Wosu, Adaeze C.; Ndyomugyenyi, Donald Bruce; Waibi, Musa; Kajungu, Dan
    There is a dearth of studies assessing non-communicable disease (NCD) mortality withinpopulation-based settings in Uganda. We assessed mortality due to major NCDs among persons 30 years in Eastern Uganda from 2010 to 2016.The study was carried out at the Iganga-Mayuge health and demographic surveillance site in the Iganga and Mayuge districts of Eastern Uganda. Information on cause of death was obtained through verbal autopsies using a structured questionnaire to conduct face-face interviews with carers or close relatives of the deceased. Physicians assigned likely cause of death using ICD-10 codes. Age-adjusted mortality rates were calculated using direct method, with the average population across the seven years of the study (2010 to 2016) as the standard. Age categories of 30–40, 41–50, 51–60, 61–70, and 71 years were used for standardization. A total of 1,210 deaths among persons 30 years old were reported from 2010 to 2016 (50.7% among women). Approximately 53% of all deaths were due to non-communicable diseases, 31.8% due to communicable diseases, 8.2% due to injuries, and 7% due to maternal-related deaths or undetermined causes. Cardiovascular diseases accounted for thevlargest proportion of NCD deaths in each year, and women had substantially higher cardio-vascular disease mortality rates compared to men. Conversely, women had lower diabetes mortality rates than men for five of the seven years examined.Non-communicable diseases are major causes of death among adults in Iganga and Mayuge; and cardiovascular diseases and diabetes are leading causes of NCD deaths.
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    Incidence and predictors of COPD mortality in Uganda: A 2-year prospective cohort study
    (PLoS One, 2021-02-11) Alupo, Patricia; Wosu, Adaeze C.; Mugenyi, Levicatus; Semakula, Daniel; Katagira, Winceslaus; Kirenga, Bruce
    Data is lacking on outcomes among COPD patients in sub-Saharan Africa. The objective of the study was to assess the incidence and predictors of mortality among COPD patients enrolled in the Uganda Registry for Asthma and COPD. What is the Incidence and predictors of mortality among COPD patients in Uganda? Individuals with a diagnosis of COPD at six hospitals in Uganda were enrolled into the registry, and followed every six months. Mortality was ascertained through post-mortem reports and verbal autopsies. Mortality rates (MR), mortality rate ratios (MRR), and hazard ratios (HR) were computed to assess associations between socio-demographic, behavioural, and clinical characteristics at enrolment into the registry and mortality up to two years after. We enrolled 296 COPD patients. Median age was 60 years, and 51·3% were male. The overall mortality rate was 95·90 deaths/1000 person-years. COPD severity by post-bronchodilator FEV1 was the strongest risk factor for mortality. Compared to stage 1, adjusted hazard ratios were as follows for stage 4: 9·86 (95%CI: 1·70–57·14, p = 0·011), stage 3: 6·16 (95%CI: 1·25–30·32, p = 0·025), and stage 2: 1·76 (95%CI: 0·33–9·48, p = 0·51). Underweight patients had a higher incidence of mortality compared to normal weight patients (MRR: 3·47 (95%CI: 1·45–8·31, p = 0·0026). Among COPD patients in Uganda, two-year mortality is high, and disease severity at baseline was the strongest risk factor for mortality. Our findings suggest the need for early, accurate, diagnosis and management of COPD, to potentially improve survival.