Browsing by Author "Wangensteen, Helle"

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    Antioxidant and anti-plasmodial activity of extracts from three Ugandan medicinal plants
    (Journal of Medicinal Plants Research, 2010) Stangeland, Torunn; Wangensteen, Helle; Katuura, Esther; Lye, Kare A.; Paulsen, Berit S.
    Extracts from three plants; Hallea rubrostipulata, Vernonia adoensis and Zanthoxylum chalybeum, were tested for antioxidant activity using three assays 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Ferric Reducing Ability of Plasma (FRAP) and total phenol content) and anti-plasmodial activity using an Enzyme-Linked Immunosorbent Assay (ELISA) on Plasmodium falciparum chloroquine sensitive strain MRA-285 line. The objective of the study was to find candidates for making anti-malarial phytomedicines. The water extract of H. rubrostipulata showed very high anti-plasmodial activity (IC50= 1.95 μg/ml) and high antioxidant activity as well. Thirteen other extracts had high anti-plasmodial activity ranging from 2.14 to 3.63 μg/ml (chloroquine IC50= 8 μg/ml). We found high correlation between the different antioxidant essays