Browsing by Author "Ssebambulidde, Kenneth"
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Item Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial(The Lancet infectious diseases, 2019-08-30) Rhein, Joshua; Tugume, Lillian; Nuwagira, Edwin; Mpoza, Edward; Kiggundu, Reuben; Ssebambulidde, Kenneth; Boulware, David R.Identifying new antifungals for cryptococcal meningitis is a priority given the inadequacy of current therapy. Sertraline has previously shown in vitro and in vivo activity against cryptococcus. We aimed to assess the efficacy and cost-effectiveness of adjunctive sertraline in adults with HIV-associated cryptococcal meningitis compared with placebo.