Browsing by Author "Mwandumba, Henry C."
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Item Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial(The Lancet Global Health, 2022-12-01) Lawrence, David S.; Tugume, Lillian; Mwandumba, Henry C.; Kanyama, Cecilia; Muzoora, Conrad; Nuwagira, Edwin; Niessen, Louis W.HIV-associated cryptococcal meningitis is a leading cause of AIDS-related mortality. The AMBITION-cm trial showed that a regimen based on a single high dose of liposomal amphotericin B deoxycholate (AmBisome group) was non-inferior to the WHO-recommended treatment of seven daily doses of amphotericin B deoxycholate (control group) and was associated with fewer adverse events. We present a five-country cost-effectiveness analysis.