Browsing by Author "Mulindwa, H."

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    Genetic Variability in Juvenile Growth Traits of Ugandan Indigenous Chicken Populations Raised under an Intensive Deep Litter System
    (Uganda Journal of Agricultural Sciences, 2025-05-02) Kiggundu, M.; Mulindwa, H.; Walusimbi, H.K.; Nangonzi, R.; Nampijja, Z.; Lumu, R.; LIsabirye, A.R.
    Uganda’s indigenous chickens (IC) display significant phenotypic diversity in body weight (BW) and growth performance. However, there has been no study on the genetic diversity related to juvenile BW and growth performance in indigenous chicken populations (ICP), to support early selection of improved growth performance. The objective of this study was to assess the genetic variation in chicken juvenile BW and growth among selected ICP in Uganda. Three populations of IC were sourced from Apac, Lira and the National Semi-Arid Resources Research Institute (NaSARRI), as founder populations. Chicks were hatched from founder eggs, wing-banded and reared under identical conditions, in a deep litter system. Body weight was recorded weekly from hatch to four weeks of age. Hatch weight was higher (P<0.01) for Apac and Lira birds compared to NaSARRI. Mean Daily gain (ADG) was greatest for Lira and lowest for NaSARRI birds. The mean relative Growth Rate (RG) of chicks from Lira and Apac was comparable, but both were greater (P<0.05) than for NaSARRI. Broad-sense heritability estimates for BW0, BW1, BW2, BW3, and BW4 were 0.35, 0.50, 0.54, 0.47, and 0.56, respectively. Genotypic variances for BW measurements varied (P<0.05) among the ICP. The heritability estimates for ADG and RG were 0.41 and 0.49, respectively, with genotype variances differing significantly (P<0.01) across the ICP for both ADG and RG. These results demonstrate both phenotypic and genotypic variability in juvenile BW and growth performance. Moderate heritability and positive phenotypic correlations suggest that these traits can be effectively improved through selective breeding.
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    The Lys-76-Thr mutation in WC/Wand chloroquine resistance in Plasmodium falciparum isolates from Uganda
    (Transactions of the Royal Society of Tropical Medicine and Hygiene, 2002) Kyosiimire-Lugemwa, J.; Nalunkuma-Kazibwe, A.J.; Mujuzi, G.; Mulindwa, H.; Talisuna, A.; Egwang, T.G.
    Recent molecular studies of chloroquine (CQ) resistance of Plasmodium falciparum have demonstrated an association between a mutation in the PƒCRT gene and CQ resistance. We identified wild type and mutant alleles of the PƒCRT codon 76 in baseline pre-CQ treatment P. falciparum isolates collected during 1999 and investigated their relationship to CQ efficacy in 3 different sites with different levels of CQ parasite resistance in Uganda. Of 32 isolates from Mulago Hospital, all were mutant (100%), while of 45 isolates from Tororo, 5 (11%) were mixed wild type and mutant and 40 (89%) were mutants only. Of 41 isolates from Apac, 13 (32%) were mixed wild type and mutant whereas 28 (68%) were mutants only. The finding of 100% prevalence of the Thr-76 mutant allele in all isolates at the 3 sites was remarkable. We found no association between the presence of Thr-76 mutation and treatment outcome at all the sites. However, the prevalence of the wild-type Lys-76 allele was higher in Apac, an area with lower CQ parasite resistance, compared to Tororo and Mulago which have relatively higher CQ parasite resistance. The Thr-76 allele as a marker of CQ resistance is probably useful in regions where the allele frequency has not yet plateaued.