Browsing by Author "Middeldorp, Jaap M."

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    Agreement between Diagnoses of Childhood Lymphoma assigned in Uganda and by an International Reference Laboratory
    (Clinical epidemiology, 2012) Orem, Jackson; Sandin, Sven; Odida, Michael; Wabinga, Henry; Mbidde, Edward; Wabwire-Mangen, Fred; Meijer, Chris JLM; Middeldorp, Jaap M.; Weiderpass, Elisabete
    Correct diagnosis is key to appropriate treatment of cancer in children. However, diagnostic challenges are common in low-income and middle-income countries. The objective of the present study was to assess the agreement between a clinical diagnosis of childhood non- Hodgkin lymphoma (NHL) assigned in Uganda, a pathological diagnosis assigned in Uganda, and a pathological diagnosis assigned in The Netherlands. The study included children with suspected NHL referred to the Mulago National Referral Hospital, Kampala, Uganda, between 2004 and 2008. A clinical diagnosis was assigned at the Mulago National Referral Hospital, where tissue samples were also obtained. Hematoxylin and eosin-stained slides were used for histological diagnosis in Uganda, and were re-examined in a pathology laboratory in The Netherlands, where additional pathological, virological and serological testing was also carried out. Agreement between diagnostic sites was compared using kappa statistics.