Browsing by Author "Marshall, Vickie"

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    Detection of Kaposi Sarcoma–Associated Herpesvirus DNA in Saliva and Buffy-Coat Samples from Children with Sickle Cell Disease in Uganda
    (The Journal of infectious diseases, 2004) Mbulaiteye, Sam M.; Pfeiffer, Ruth M.; Engels, Eric A.; Marshall, Vickie; Bakaki, Paul M.; Owor, Anchilla M.; Ndugwa, Christopher M.; Mbidde, Edward Katongole; Goedert, James J.; Biggar, Robert J.; Whitby, Denise
    Among 233 children, Kaposi sarcoma–associated herpesvirus (KSHV) DNA was detected in 43% of children seropositive for both K8.1 and orf73, in 29% of children seropositive for K8.1 only, in 14% of children seropositive for orf73 only, and in 7% of children seronegative for both K8.1 and orf73; among 228 mothers, KSHV DNA was detected in 27%, 25%, 4%, and 1%, respectively. KSHV DNA was detected more frequently and at higher levels in saliva than in buffy-coat samples and in children than in mothers. In both children and mothers, detection in saliva was associated with detection in peripheral blood. Detection was associated with K8.1 seropositivity, younger age, and high household density, indicating the importance of in-household person-to-person transmission, likely via saliva.
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    Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda
    (Cancer epidemiology,, 2018) Juan, Ravell; Otim, Isaac; Nabalende, Hadijah; Legason, Ismail D.; Reynolds, Steven J.; Ogwang, Martin D.; Ndugwa, Christopher M.; Marshall, Vickie; Whitby, Denise; Goedert, James J.; Engels, Eric A.; Bhatia, Kishor; Lenardo, Michael J.; Mbulaiteye, Sam M.
    Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods: Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results: Plasma Mg2+ deficiency (plasma level<1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation: Plasma Mg2+ deficiency is associated with high EBV levels and eBL.