Browsing by Author "Kimanje, Kyobe Ronald"

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    Hypoglycemic and Toxic Effect of Morus mesozygia Leaf Extract on the Liver and Kidneys of Alloxan-Induced Hyperglycemic Wistar Rats
    (Hindawi, 2019) Tirwomwe, Michael; Echoru, Isaac; Maseruka, Richard; Kimanje, Kyobe Ronald; Byarugaba, Wilson
    Diabetes mellitus (DM) is one of the leading causes of mortality and morbidity in developed and developing countries. DM is characterized by increased levels of glucose that eventually progress to frequent urination, increased thirst, and increased hunger [1]. According to global estimates of diabetes, in 2013, 382 million people had diabetes; this number is however expected to rise to 592 million by 2035. Majority of the people with diabetes live in low- and middle-income countries and these will experience the greatest increase in cases of diabetes over the next 22 years [2]. In Africa alone, about 12.1 million people lived with diabetes mellitus by 2010 [3, 4], and according to research, there will be an expected increment in the prevalence of DM in Asia and Africa by 2030. )is is because of increased urbanization and lifestyle changes that have changed the indigenous diet to a modern diet [5].
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    Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster
    (Journal of Complementary and Integrative Medicine, 2020) Ayikobua, Emmanuel Tiyo; Kasolo, Josephine; Kasozi, Keneth Iceland; Eze, Ejike Daniel; Safiriyu, Abass; Ninsiima, Herbert Izo; Kiyimba, Kennedy; Namulema, Jackline; Jjesero, Edward; Ssempijja, Fred; Semuyaba, Ibrahim; Kimanje, Kyobe Ronald; Kalange, Muhamudu; Okpanachi, Alfred Omachonu; Nansunga, Miriam
    The Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. This research was targeted toward determining the effects of ethanolic extract of propolis, with levodopa therapy in the management of Parkinsonism. The PINK1B9 flies were divided into groups and fed with the different treatment doses of ethanoic extract of propolis. The treatment groups were subjected to 21 days of administration of propolis and the levodopa at different doses after which percentage climbing index, antioxidant activity and lifespan studies were done.Propolis alone improved motor activity, antioxidant and lifespan in Drosophila melanogaster than in PINK1 flies. Propolis in combination with levodopa significantly (P<0.05) improved physiological parameters at higher than lower concentrations in Parkinsonism Drosophila melanogaster demonstrating its importance in managing side effects associated with levodopa. Propolis is a novel candidate as an alternative and integrative medicinal option to use in the management of Parkinsonism in both animals and humans at higher concentrations.