Browsing by Author "Galiwango, Edward"

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    Adverse Perinatal Events, Treatment Gap, and Positive Family History Linked to the High Burden of Active Convulsive Epilepsy in Uganda: A Population-Based Study
    (Epilepsia Open, 2017) Mwesige, Angelina Kakooza; Ndyomugyenyi, Donald; Pariyo, George; Peterson, Stefan Swartling; Waiswa, Paul Michael; Galiwango, Edward; Chengo, Eddie; Odhiambo, Rachael; Ssewanyana, Derrick; Bottomley, Christian; Ngugi, Anthony K.; Newton, Charles R. J. C.
    To determine the prevalence of active convulsive epilepsy (ACE) and describe the clinical characteristics and associated factors among a rural Ugandan population.The entire population in Iganga/Mayuge Health Demographic Surveillance Site (IM-HDSS) was screened using two questions about seizures during a door-to-door census exercise. Those who screened positive were assessed by a clinician to confirm diagnosis of epilepsy. A case control study with the patients diagnosed with ACE as the cases and age/sex-matched controls in a ratio of 1:1 was conducted.A total of 64,172 (92.8%) IM-HDSS residents, with a median age of 15.0 years (interquartile range [IQR]: 8.0–29.0), were screened for epilepsy. There were 152 confirmed ACE cases, with a prevalence of 10.3/1,000 (95% confidence interval [CI]: 9.5–11.1) adjusted for nonresponse and screening sensitivity. Prevalence declined with age, with the highest prevalence in the 0–5 years age group. In an analysis of n = 241 that included cases not identified in the survey, nearly 70% were unaware of their diagnosis. Seizures were mostly of focal onset in 193 (80%), with poor electroencephalogram (EEG) agreement with seizure semiology. Antiepileptic drug use was rare, noted in 21.2% (95% CI: 16.5–25.8), and 119 (49.3%) reported using traditional medicines. History of an abnormal antenatal period (adjusted odds ratio [aOR] 10.28; 95%CI 1.26–83.45; p = 0.029) and difficulties in feeding, crying, breathing in the perinatal period (aOR 10.07; 95%CI 1.24–81.97; p = 0.031) were associated with ACE in children. In adults a family history of epilepsy (aOR 4.38 95%CI 1.77–10.81; p = 0.001) was the only factor associated with ACE.There is a considerable burden of epilepsy, low awareness, and a large treatment gap in this population of rural sub-Saharan Africa. The identification of adverse perinatal events as a risk factor for developing epilepsy in children suggests that epilepsy burden may be decreased by improving obstetric and postnatal care.
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    Cohort Profile: The Iganga-Mayuge Health and Demographic Surveillance Site, Uganda (IMHDSS, Uganda)
    (International journal of epidemiology, 2020) Kajungu, Dan; Hirose, Atsumi; Rutebemberwa, Elizeus; Pariyo, George W; Peterson, Stefan; Guwatudde, David; Galiwango, Edward; Tusubira, Valerie; Kaija, Judith; Nareeba, Tryphena; Hanson, Claudia
    The Iganga Mayuge Health and Demographic Surveillance Site (IMHDSS) was set up in 2004 to provide a platform for community-based epidemiological research and research training. Seed funding was provided by the Swedish International Development Agency (SIDA) as part of the Karolinska Institutet, Sweden and Makerere University– Sweden bilateral research collaboration. The specific objectives at inception were to (i) register and monitor health and demographic events (births, deaths, migration) and dynamics in a population and serve as a resource of information for decision making, providing an environment for several community-based projects in single-/multi-disciplinary research and research training; (ii) provide unique, essential, household-level information individually tailored for policy, planning and research needs; (iii) provide a platform for training in applied field research and practical health, socioeconomic and demographic survey methods to students, staff and researchers; and (iv) provide a platform for high-quality household survey data for operational field trials that measures interventions including but not limited to, monitoring trends in communicable and noncommunicable diseases (NCDs), clinical and vaccine trials and other surveillance activities.
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    Randomised Comparison Of Two Household Survey Modules For Measuring Stillbirths And Neonatal Deaths In Five Countries: The Every Newborn-INDEPTH Study
    (The Lancet Global Healt, 2020) Akuze, Joseph; Blencowe, Hannah; Waiswa, Peter; Baschieri, Angela; Gordeev, Vladimir S; Kwesiga, Doris; Fisker, Ane B.; Thysen, Sanne M.; Rodrigues, Amabelia; Biks, Gashaw A.; Abebe, Solomon M.; Gelaye, Kassahun A.; Mengistu, Mezgebu Y.; Geremew, Bisrat M.; Delele, Tadesse G.; Tesega, Adane K.; Yitayew, Temesgen A.; Kasasa, Simon; Galiwango, Edward; Natukwatsa, Davis; Kajungu, Dan; Enuameh, Yeetey A.K.; Nettey, Obed E.; Dzabeng, Francis; Amenga-Etego, Seeba; Newton, Sam K.; Tawiah, Charlotte; Asante, Kwaku P.; Owusu-Agyei, Seth; Alam, Nurul; Haider, Moinuddin M.; Imam, Ali; Mahmud, Kaiser; Cousens, Simon; Lawn, Joy E.
    An estimated 5·1 million stillbirths and neonatal deaths occur annually. Household surveys, most notably the Demographic and Health Survey (DHS), run in more than 90 countries and are the main data source from the highest burden regions, but data-quality concerns remain. We aimed to compare two questionnaires: a full birth history module with additional questions on pregnancy losses (FBH+; the current DHS standard) and a full pregnancy history module (FPH), which collects information on all livebirths, stillbirths, miscarriages, and neonatal deaths.
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    A Randomized Trial of Low-Cost Mesh in Groin Hernia Repair
    (New England Journal of Medicine, 2016) Löfgren, Jenny; Nordin, Pär; Ibingira, Charles; Matovu, Alphonsus; Galiwango, Edward; Wladis, Andreas
    The most effective method for repair of a groin hernia involves the use of a synthetic mesh, but this type of mesh is unaffordable for many patients in low- and middle-income countries. Sterilized mosquito meshes have been used as a lower cost alternative but have not been rigorously studied.