Browsing by Author "Gabrieladela, Fuente"

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    Evaluation of effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial
    (NPJ Vaccines, 2024) Kabi, Fredrick; Marinela, Contreras; Semakula, Jimmy; MartaSánchez-Sánchez; Clara, Muñoz-Hernández; Mugerwa, Swidiq; Kasaija, Paul; Kirunda, Halid; Gabrieladela, Fuente; Ruben, Fernandez-Melgar; Marta, Rafael; Isabel, G. Fernández de Mera; Matovu, Moses; Kyakuwa, Ivan; Dhikusooka, Moses; Nsereko, Godfrey; Boma, Paul; Bugeza, James; Mwesigwa, Moses; Namukasa, Agnes; Obonyo, Philip; Ssekabunga, Nicholas; Adyero, Okeny E.; Rutaisire, Justus; Christian, Gortazar; José de la Fuente
    Vaccines are the most effective and sustainable intervention to control ticks and tick-borne disease (TBD). Using a personalized vaccine design based on regional tick genotypes, a Rhipicephalus appendiculatus Subolesin protective antigen was used in a field trial evaluating tick vaccine efficacy, effectiveness, and safety in cattle infested with multiple tick species in different Ugandan agro ecological zones. Vaccination with SUB was safe with a protective capacity against anemia and infection, and reduced the number of infested cattle, tick fitness (feeding and reproduction)with vaccine effectivenessagainstmultipletickspeciesbetween93.2%at167-196dayspost-vaccination(dpv)and 61.4% at 251–327 dpv. Total integrated vaccine efficacy/effectiveness was estimated as 98.8%. The Subolesin-based vaccine is protective against multiple cattle tick infestations under field conditions in Uganda. These results support registration and commercialization of the vaccine to reduce tick populations and associated risks for human and animal TBD and chemical acaracides in Uganda.