Browsing by Author "Dhikusooka, Moses"

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    Evaluation of effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial
    (NPJ Vaccines, 2024) Kabi, Fredrick; Marinela, Contreras; Semakula, Jimmy; MartaSánchez-Sánchez; Clara, Muñoz-Hernández; Mugerwa, Swidiq; Kasaija, Paul; Kirunda, Halid; Gabrieladela, Fuente; Ruben, Fernandez-Melgar; Marta, Rafael; Isabel, G. Fernández de Mera; Matovu, Moses; Kyakuwa, Ivan; Dhikusooka, Moses; Nsereko, Godfrey; Boma, Paul; Bugeza, James; Mwesigwa, Moses; Namukasa, Agnes; Obonyo, Philip; Ssekabunga, Nicholas; Adyero, Okeny E.; Rutaisire, Justus; Christian, Gortazar; José de la Fuente
    Vaccines are the most effective and sustainable intervention to control ticks and tick-borne disease (TBD). Using a personalized vaccine design based on regional tick genotypes, a Rhipicephalus appendiculatus Subolesin protective antigen was used in a field trial evaluating tick vaccine efficacy, effectiveness, and safety in cattle infested with multiple tick species in different Ugandan agro ecological zones. Vaccination with SUB was safe with a protective capacity against anemia and infection, and reduced the number of infested cattle, tick fitness (feeding and reproduction)with vaccine effectivenessagainstmultipletickspeciesbetween93.2%at167-196dayspost-vaccination(dpv)and 61.4% at 251–327 dpv. Total integrated vaccine efficacy/effectiveness was estimated as 98.8%. The Subolesin-based vaccine is protective against multiple cattle tick infestations under field conditions in Uganda. These results support registration and commercialization of the vaccine to reduce tick populations and associated risks for human and animal TBD and chemical acaracides in Uganda.
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    Monitoring the Subolesin Vaccine Field Trial for Safer Control of Cattle Ticks Amidst Increasing Acaricide Resistance in Uganda
    (Vaccines, 2022) Kabi, Fredrick; Dhikusooka, Moses; Matovu, Moses; Mugerwa, Swidiq; Kasaija, Paul; Emudong, Patrick; Kirunda, Halid; Contreras, Marinela; Gortazar, Christian; De la Fuente, Jose
    A collaboration program was established between the group of Health and Biotechnology (SaBio) of the IREC Institute of Game and Wildlife Research (CSIC-UCLM-JCCM, Spain) and the National Agricultural Research Organization of Uganda (NARO) for the development of vaccines for the control of cattle ticks in Uganda. Controlled pen trials identified a tick protective antigen, Rhipicephalus appendiculatus Subolesin, and a cross-species-effective vaccine formulation. As the next step, a controlled vaccine field trial has been approved by Ugandan state regulatory authorities, the Uganda National Council for Science and Technology (UNCST) and the National Drug Authority (NDA), to evaluate the efficacy and effectiveness of the vaccine formulation for the control of cattle tick infestations under field conditions. The results of this trial may lead to the approval of the vaccine for application in Uganda to improve cattle health and production while reducing the use of acaricides.