Browsing by Author "Bliss, Sandra J."
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Item The Evidence For Using Conjugate Vaccines To Protect HIV-Infected Children Against Pneumococcal Disease(The Lancet infectious diseases, 2008) Bliss, Sandra J.; O’Brien, Katherine L.; Janoff, Edward N.; Cotton, Mark F.; Musoke, Philippa; Coovadia, Hoosen; Levine, Orin S.Pneumococcal conjugate vaccines (PCVs) are a potentially useful complement to existing treatment strategies in HIV-infected children, for whom pneumococcal infections are common and serious. This Review summarises available data on the burden of pneumococcal disease and the safety and efficacy of PCVs in HIV-infected children. The data demonstrate that children with HIV have significantly increased risk of pneumococcal disease compared with uninfected children; the serotypes included in currently licensed or near-licensure conjugate vaccines include most serotypes that cause invasive pneumococcal disease (IPD) in HIV-infected children and adults; PCVs provide substantial protection against IPD and clinical pneumonia when given to HIV-infected infants; and HIV-infected adults gain an indirect benefit when children in the community are vaccinated. PCV should be considered as an important intervention for improving the lives of HIV-infected children.