Browsing by Author "Angupale, Jimmy R."

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    Physical Properties and Compactability of Various Blends of Fully Gelatinised and Pregelatinised Maize Starch
    (Pharmaceutical and Biosciences Journal, 2020) Angupale, Jimmy R.; Engeu Ogwang, Patrick; Okafor, Sylvester I.
    The use of pregelatinised maize starch in direct compression as a sole binder produces tablets with relatively low tensile strength. Fully gelatinised maize starch possesses better binding properties but its use is limited in immediate release tablets. The aim of this work was to prepare a blend of fully gelatinised and pregelatinised maize starch possessing optimum tabletting properties. The pregelatinised starch was prepared by heating a 15 % slurry at 65 ℃ for 15 min followed by filtration and drying. The fully gelatinised starch was prepared by heating a 10 % slurry at 80 ℃ for 5min followed by precipitation with acetone, filtration and drying. The two samples were blended in 100:0, 25:75, 50:50, 75:25 and 0:100 proportions. Both local and BP starch samples were used and their blends compared for flow, packing characteristics and compactability. The disintegration time of the compacts was also determined. The results indicated that the BP starch blends exhibited better tabletting properties compared to the local starch. The proportion with 100 % fully gelatinised starch showed the best flow and compactability.
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    Wound Healing Property and Phytochemical Analysis of Zanthoxylum Species from Uganda
    (Journal of Pharmaceutical Research International, 2017) Engeu Ogwang, Patrick; Oloro, Joseph; Angupale, Jimmy R.; Baruga, Evariste
    The study evaluated the efficacy and possible mechanism of the stem bark of Zanthoxylum species used by communities and herbalists for wound healing in South Western Uganda. Study Design: Experimental controlled. Place and Duration: Departments of Pharmacy, Pharmacology and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology. The study done between August 2016 and February 2017. Excision wounds were humanely made on the bark of healthy albino rats and then randomly divided into four groups i.e Group I (Zanthoxylum spp (Zanthoxylum species) water extract) n=9, Group 2 (control herbal drug) n=6, Group 3 (distilled water) n=9 and Group 4 (neomcycine antibiotic) n=3. Treatments were applied twice a day for 15 days. The wound areas determined at baseline (day 1), then at day 6 and day 15 for each of the animals in groups 1, 2 and 3. Percentage reduction in wound areas was determined on day 6 and 15 and statistically compared. On day 7 the rats in group 4 and three rats randomly picked by a blinded laboratory technician from groups 1 and 3 were humanely sacrificed for histology examination of wound tissues. Phytochemical analysis of the water extract of Zanthoxylum spp and the effect of the various solvent on extract efficacy were also evaluated.