Genetic and Shared Environmental Influences on Interferon-g Production in Response to Mycobacterium tuberculosis Antigens in a Ugandan Population

Simple item page
dc.contributor.authorTao, Li
dc.contributor.authorZalwango, Sarah
dc.contributor.authorChervenak, Keith
dc.contributor.authorThiel, Bonnie
dc.contributor.authorMalone, LaShaunda L.
dc.contributor.authorFeiyou, Qiu
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorBoom, Henry
dc.contributor.authorStein, Catherine M.
dc.date.accessioned2021-12-10T11:07:08Z
dc.date.available2021-12-10T11:07:08Z
dc.date.issued2010
dc.description.abstractInterferon-g (IFN-g) is a key cytokine in the immune response to Mycobacterium tuberculosis (Mtb). Many studies established IFN-g responses are influenced by host genetics, however differed widely by the study design and heritability estimation method. We estimated heritability of IFN-g responses to Mtb culture filtrate (CF), ESAT-6, and Antigen 85B (Ag85B) in 1,104 Ugandans from a household contact study. Our method separately evaluates shared environmental and genetic variance, therefore heritability estimates were not upwardly biased, ranging from 11.6% for Ag85B to 22.9% for CF. Subset analyses of individuals with latent Mtb infection or without human immunodeficiency virus infection yielded higher heritability estimates, suggesting 10–30% of variation in IFN-g is caused by a shared environment. Immunosuppression does not negate the role of genetics on IFN-g response. These estimates are remarkably close to those reported for components of the innate immune response. These findings have implications for the interpretation of IFN-g response assays and vaccine studies.en_US
dc.identifier.citationTao, L., Zalwango, S., Chervenak, K., Thiel, B., Malone, L. L., Qiu, F., ... & Tuberculosis Research Unit (TBRU. (2013). Genetic and shared environmental influences on interferon-γ production in response to Mycobacterium tuberculosis antigens in a Ugandan population. The American journal of tropical medicine and hygiene, 89(1), 169. doi:10.4269/ajtmh.12-0670en_US
dc.identifier.other10.4269/ajtmh.12-0670
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/243
dc.language.isoenen_US
dc.publisherThe American Society of Tropical Medicine and Hygieneen_US
dc.subjectGeneticen_US
dc.subjectEnvironmental Influencesen_US
dc.subjectProductionen_US
dc.subjectMycobacterium tuberculosis Antigensen_US
dc.subjectUgandan Populationen_US
dc.titleGenetic and Shared Environmental Influences on Interferon-g Production in Response to Mycobacterium tuberculosis Antigens in a Ugandan Populationen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Genetic and Shared Environmental Influences on Interferon-g Production in Response.pdf
Size:
662.87 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences