What’s new in sepsis recognition in resource‑limited settings?

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Date
2016Author
Kwizera, Arthur
Festic, Emir
Dünser, Martin W.
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Show full item recordAbstract
Sepsis is a life-threatening condition characterized by one or more organ dysfunctions due to a dysregulated host
response to infection [1] or, in certain cases, due to direct pathogen effects. Sepsis is not only associated with bacterial
or fungal infections but also with any other infection such as viral disease, protozoal (e.g., malaria), or tropical
infections. Although the literature suggests that sepsis is predominantly a healthcare issue in resource-rich countries,
the global burden of acute infections is highest in resource-limited areas [2]. Successful sepsis management
relies on various components of which early recognition is essential. Evidence and recommendations for sepsis
recognition are mainly based on research performed in resource-rich settings [3]. However, resource-rich and
-limited countries differ in healthcare accessibility [4] and infectious disease epidemiology [5–7]. It is therefore
unreasonable to directly translate evidence between these settings.
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