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Human Immunodeficiency Virus Infection And Cerebral Malaria In Children In Uganda: A Case-Control Study

Imani, Peace D.; Musoke, Philippa; Byarugaba, Justus; Tumwine, James K. (BMC pediatrics, 2011)

Human immunodeficiency virus (HIV)-1 infection increases the burden of malaria by increasing susceptibility to infection and decreasing the response to malarial treatment. HIV-1 has also been found to suppress the immune ...

Pharmacokinetics and Safety of Zidovudine, Lamivudine, and Lopinavir/Ritonavir in HIV-infected Children With Severe Acute Malnutrition in Sub-Saharan Africa: IMPAACT Protocol P1092

Owor, Maxensia; Tierney, Camlin; Ziemba, Lauren; Browning, Renee; Moye, John; Graham, Bobbie; Reding, Christina; Costello, Diane; Norman, Jennifer; Wiesner, Lubbe; Hughes, Emma; Whalen, Meghan E.; Purdue, Lynette; Mmbaga, Blandina Theophil; Kamthunzi, Portia; Kawalazira, Rachel; Nathoo, Kusum; Bradford, Sarah; Coletti, Anne; Aweeka, Francesca; Musoke, Philippa (The Pediatric Infectious Disease Journal, 2021)

Severe acute malnutrition (SAM) may alter the pharmacokinetics (PK), efficacy, and safety of antiretroviral therapy. The phase IV study, IMPAACT P1092, compared PK, safety, and tolerability of zidovudine (ZDV), lamivudine ...

A hospital-based birth defects surveillance system in Kampala, Uganda

Mumpe-Mwanja, Daniel; Barlow-Mosha, Linda; Williamson, Dhelia; Valencia, Diana; Serunjogi, Robert; Kakande, Ayoub; Namale-Matovu, Joyce; Nankunda, Jolly; Birabwa-Male, Doreen; Okwero, Margaret Achom; Nsungwa-Sabiiti, Jesca; Musoke, Philippa (BMC pregnancy and childbirth, 2019)

Background: In 2010, the World Health Assembly passed a resolution calling upon countries to prevent birth defects where possible. Though birth defects surveillance programs are an important source of information to guide ...

Adherence To Antiretroviral Therapy In Children Attending Mulago Hospital, Kampala

Barungi, Nicolette Nabukeera; Kalyesubula, Israel; Kekitiinwa, Addy; Tusiime, Jayne Byakika; Musoke, Philippa (Annals of tropical paediatrics, 2007)

Non-adherence reduces the effectiveness of antiretroviral therapy in children attending the paediatric HIV/AIDS clinic at Mulago Hospital, Kampala.To determine the levels of adherence to HAART and identify factors associated ...

A Phase I/II Study Of The Safety And Pharmacokinetics Of Nevirapine In HIV-1-Infected Pregnant Ugandan Women And Their Neonates (HIVNET 006)

Musoke, Philippa; Guay, Laura A.; Bagenda, Danstan; Mirochnick, Mark; Nakabiito, Clemensia; Fleming, Thomas; Elliott, Terry; Horton, Scott; Dransfield, Kevin; Pav, Joseph W.; Murarka, Amal; Allen, Melissa; Fowler, Mary Glenn; Mofenson, Lynne; Hom, David; Mmiro, Francis; Jackson, J. Brooks (Aids, 1999)

To determine the safety, pharmacokinetics, tolerance, antiretroviral activity, and infant HIV infection status after giving a single dose of nevirapine to HIV-1-infected pregnant women during labor and their newborns during ...

Bacteremia, Causative Agents and Antimicrobial Susceptibility Among HIV-1–infected Children on Antiretroviral Therapy in Uganda and Zimbabwe

Musiime, Victor; Cook, Adrian; Bakeera-Kitaka, Sabrina; Vhembo, Tichaona; Lutakome, Joseph; Keishanyu, Rosette; Prendergast, Andrew J.; Lubwama, Sam; Robertson, Val; Hughes, Peter; Nathoo, Kusum; Munderi, Paula; Klein, Nigel; Musoke, Philippa; Gibb, Diana M. (The Pediatric infectious disease journal, 2013)

Bacteremia is common in HIV-infected children in Africa, including after start of antiretroviral therapy (ART), but there are limited data on causative pathogens and their antimicrobial sensitivity patterns in this ...

Associations of Chemokine Receptor Polymorphisms With HIV-1 Mother-to-Child Transmission in Sub-Saharan Africa: Possible Modulation of Genetic Effects by Antiretrovirals

Singh, Kumud K.; Hughes, Michael D.; Chen, Jie; Phiri, Kelesitse; Rousseau, Christine; Kuhn, Louise; Coutsoudis, Anna; Jackson, J. Brooks; Guay, Laura A.; Musoke, Philippa; Mmiro, Francis; Semba, Richard D.; Spector, Stephen A. (Journal of acquired immune deficiency syndromes, 2008)

HIV-1 mother-to-child transmission (MTCT) remains an important route of infection in sub-Saharan Africa.Genetic variants in CCR5 promoter, CCR2, CX3CR1, and Stromal cell-derived factor-1 (SDF-1) genes were determined in ...

Characterization of Nevirapine Resistance Mutations in Women With Subtype A Vs. D HIV-1 6–8 Weeks After Single-Dose Nevirapine (HIVNET 012)

Eshleman, Susan H.; Guay, Laura A.; Mwatha, Anthony; Brown, Elizabeth R.; Cunningham, Shawn P.; Musoke, Philippa; Mmiro, Francis; Jackson, J. Brooks (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2004)

To compare the number and type of nevirapine (NVP) resistance mutations detected in Ugandan women with subtype A vs.D HIV-1 infection after single-dose NVP prophylaxis.In the HIVNET 012 trial, a higher rate of NVP resistance ...

Transition To Adult Care: Exploring Factors Associated With Transition Readiness Among Adolescents And Young People In Adolescent ART clinics in Uganda

Mbalinda, Scovia Nalugo; Kitaka, Sabrina Bakeera; Lusota, Derrick Amooti; Musoke, Philippa; Nyashanu, Mathew; Kaye, Dan Kabonge (PloS one, 2021)

Transition readiness refers to a client who knows about his/her illness and oriented towards future goals and hopes, shows skills needed to negotiate healthcare, and can assume responsibility for his/ her treatment, and ...

Adherence to antiretroviral therapy in children attending Mulago Hospital, Kampala

Nabukeera-Barungi, Nicolette; Kalyesubula, Israel; Kekitiinwa, Addy; Byakika-Tusiime, Jayne; Musoke, Philippa (Annals of tropical Paediatrics, 2007)

Background: Non-adherence reduces the effectiveness of antiretroviral therapy in children attending the paediatric HIV/AIDS clinic at Mulago Hospital, Kampala. Aim: To determine the levels of adherence to HAART and ...

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