Nachega, Jean B.Agudu, Nadia A. SamBudhram, SamanthaTaha, Taha E.Vannevel, ValerieSomapillay, PriyaIshoso, Daniel KatuashiPipo, Michel TshiasumaNswe, Christian Bongo-PasiDitekemena, JohnAyele, Birhanu T.Machekano, Rhoderick N.Gachuno, Onesmus W.Kinuthia, JohnMwongeli, NancySekikubo, MusaMusoke, PhilippaAgbeno, Evans KofiUmar, Lawal W.Ntakwinja, MukanireMukwege, Denis M.Smith, Emily R.Mills, Eduard J.Otshudiema, John OtokoyeKingebeni, Placide MbalaKayembe, Jean-Marie N.Landu, Don Jethro MavunguTamfum, Jean-Jacques MuyembeZumla, AlimuddinLangenegger, Eduard J.Mofenson, Lynne M.2022-01-292022-01-292021Nachega, J. B., Sam-Agudu, N. A., Budhram, S., Taha, T. E., Vannevel, V., Somapillay, P., ... & AFREhealth COVID-19 Research Collaboration Working Group. (2021). Effect of SARS-CoV-2 infection in pregnancy on maternal and neonatal outcomes in Africa: an AFREhealth call for evidence through multicountry research collaboration. The American Journal of Tropical Medicine and Hygiene, 104(2), 461.https://nru.uncst.go.ug/xmlui/handle/123456789/1596In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research is critically needed to evaluate the effects of the added burden of COVID-19 in pregnancy, to help develop evidence-based policies toward improving maternal and infant outcomes. In this perspective, we briefly review current knowledge on the clinical features of COVID-19 in pregnancy; the risks of preterm birth and cesarean delivery secondary to comorbid severity; the effects of maternal SARS-CoV-2 infection on the fetus/neonate; and in utero mother-to-child SARS-CoV-2 transmission. We further highlight the need to conduct multicountry surveillance as well as retrospective and prospective cohort studies across SSA. This will enable assessments of SARS-CoV-2 burden among pregnant African women and improve the understanding of the spectrum of COVID-19 manifestations in this population, which may be living with or without HIV, TB, and/or other coinfections/comorbidities. In addition, multicountry studies will allow a better understanding of risk factors and outcomes to be compared across countries and subregions. Such an approach will encourage and strengthen much-needed intra-African, south-to-south multidisciplinary and interprofessional research collaborations. The African Forum for Research and Education in Health’s COVID-19 Research Working Group has embarked upon such a collaboration across Western, Central, Eastern and Southern Africa.enArticle