Kajoba, DicksonEgesa, Walufu IvanPetit, Habonimana JeanLaker, GorettyWaibi, William MugowaAsiimwe, Daniel2023-04-122023-04-122021Kajoba, D., Ivan Egesa, W., Jean Petit, H., Omar Matan, M., Laker, G., Mugowa Waibi, W., & Asiimwe, D. (2021). Congenital malaria in a 2-day-old neonate: a case report and literature review. Case Reports in Infectious Diseases, 2021.https://doi.org/10.1155/2021/9960006https://nru.uncst.go.ug/handle/123456789/8446Congenital malaria is the presence of malaria parasites in a blood smear obtained from a neonate usually within 24 hours to 7 days of life. It has for long been regarded a rare condition. However, recent data indicate that congenital malaria complicates around 35.9% of live births globally, 0–37% in Sub-Saharan Africa and about 4–6.1% in Eastern Uganda. We present a 2-day-old neonate who presented with fever, irritability, and failure to breastfeed. Laboratory tests indicated that the neonate had a positive Giemsa-stained peripheral smear for Plasmodium falciparum, with a positive malaria rapid diagnostic test (MRDT) for P. falciparum malaria. The mother had a negative peripheral film for malaria and a negative MRDT. The neonate was managed with intravenous artesunate with improvement.enCongenital MalariaNeonateCase ReportArticle