Madut Akech, GabrielKanyike, Andrew MarvinGalabuzi Nassozi, AshahAguti, BeatriceNakawuki, Ashley WinfredKimbugwe, DenisKiggundu, JosenMaiteki, RobertMukyala, DorothyBongomin, FelixObakiro, Samuel BakerNekaka, RebeccaIramiot, Jacob Stanley2023-02-262023-02-262022Akech, G. M. M., Kanyike, A. M., Nassozi, A. G., Aguti, B., Nakawuki, A. W., Kimbugwe, D., ... & Iramiot, J. S. (2022). COVID-19 Vaccination Uptake and Self-Reported Side Effects among Healthcare Workers in Mbale City Eastern Uganda. medRxiv, 2022-07. https://doi.org/10.1101/2022.07.11.22277490https://doi.org/10.1101/2022.07.11.22277490https://nru.uncst.go.ug/handle/123456789/7983Fear of anticipated side effects has hindered the COVID-19 vaccination program globally. We report the uptake and the self-reported side effects (SEs) of the COVID-19 vaccine among Healthcare workers (HCWs) in Mbale City Eastern Uganda. Methods: A cross-sectional survey of HCWs at seven different level health facilities was conducted from 6th September to 7th October 2021 using a structured self-administered questionnaire. Results: COVID-19 vaccine had been received by 119 (69%) participants of which 79 (66%) received the two recommended doses of the AstraZeneca vaccine. Getting vaccinated was associated with working in a lower health facility (aOR= 14.1, 95% CI: 4.9 – 39.6, P=0.000), perceived minor risk of contracting COVID-19 (aOR= 12.3, 95% CI: 1.0 – 44.6, p=0.047), and agreeing that COVID-19 vaccine is protective (aOR= 16.7, 95% CI: 5.6 – 50.4, p=0.000). 97 (82%) of participants experienced side effects to at least one dose of which most were mild on both the first (n=362, 51%) and second dose (n=135, 69%). The most frequently reported side effects on the first and second dose were fever (79% and 20%), injection site pain (71% and 25%), and Fatigue (69% and 20%) respectively. Conclusions: The majority of the HCWs in Mbale City had received at least one dose of the COVID-19 vaccine and experienced a side effect. The side effects were mostly mild on either dose thus the vaccines are generally safe.enCOVID-19 vaccineAssociated factorsSide effectsHealthcare workersEastern UgandaArticle