Jaganath, DevanWobudeya, EricSekadde, Moorine P.Nsangi, BettyHaq, HeatherCattamanchi, Adithya2022-12-222022-12-222019Jaganath D, Wobudeya E, Sekadde MP, Nsangi B, Haq H, Cattamanchi A (2019) Seasonality of childhood tuberculosis cases in Kampala, Uganda, 2010-2015. PLoS ONE 14(4): e0214555. https://doi.org/10.1371/journal. pone.0214555https://doi.org/10.1371/journal. pone.0214555https://nru.uncst.go.ug/handle/123456789/6484Seasonality in tuberculosis (TB) has been described, especially in children. However, few studies have assessed seasonality of TB in the equatorial region, and none in children. Objectives To assess for seasonality of childhood TB cases in Kampala, Uganda, and determine the role of temperature, rainfall patterns, and influenza cases on TB diagnoses. Methods We retrospectively analyzed demographic and clinical data of children (under 15 years) diagnosed with TB at a pediatric TB clinic in Kampala, Uganda from 2010 to 2015. We performed decomposition analysis of the monthly case time series to assess seasonality. We compared monthly mean plots and performed Poisson regression to assess any association between TB diagnoses and temperature, rainfall, and influenza. Results Of the 713 childhood TB cases diagnosed at the clinic, 609 (85%) were clinically diagnosed and 492 (69%) were pulmonary cases. There were minimal monthly variations in TB cases, with a trough in December and peaks in July and October, but there was no significant seasonality. Temperature variations did not show a clear pattern with TB diagnoses. Rainfall alternated with TB diagnoses in the first half of the year, but then overlapped in the second half and was significantly associated with TB diagnoses. Influenza cases were significantly related to TB diagnoses with (β = 0.05, 95% CI 0.01 to 0.09, p = 0.01) or without (β = 0.06, 95% CI 0.01 to 0.1, p = 0.01) rainfall, and had particular overlap with pulmonary TB cases.enchildhoodtuberculosisTB clinicArticle