Stangeland, TorunnWangensteen, HelleKatuura, EstherLye, Kare A.Paulsen, Berit S.2021-12-142021-12-142010Stangel, T., Wangensteen, H., Katuura, E., Lye, K. A., & Paulsen, B. S. (2010). Antioxidant and anti-plasmodial activity of extracts from three Ugandan medicinal plants. Journal of Medicinal Plants Research, 4(18), 1916-1923.DOI: 10.5897/JMPR10.446ISSN 1996-0875https://nru.uncst.go.ug/xmlui/handle/123456789/491Extracts from three plants; Hallea rubrostipulata, Vernonia adoensis and Zanthoxylum chalybeum, were tested for antioxidant activity using three assays 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Ferric Reducing Ability of Plasma (FRAP) and total phenol content) and anti-plasmodial activity using an Enzyme-Linked Immunosorbent Assay (ELISA) on Plasmodium falciparum chloroquine sensitive strain MRA-285 line. The objective of the study was to find candidates for making anti-malarial phytomedicines. The water extract of H. rubrostipulata showed very high anti-plasmodial activity (IC50= 1.95 μg/ml) and high antioxidant activity as well. Thirteen other extracts had high anti-plasmodial activity ranging from 2.14 to 3.63 μg/ml (chloroquine IC50= 8 μg/ml). We found high correlation between the different antioxidant essaysenHallea rubrostipulataVernonia adoensisZanthoxylum chalybeum2,2-Diphenyl-1-picrylhydrazylFluorescence recovery after photobleachingTotal phenolic compoundsArticle