Weiner, JanuaryMaertzdorf, JeroenSuliman, SaraHanekom, Willem A.Mayanja-Kizza, HarrietKaufmann, Stefan H.E.GC6-74 consortium2022-05-252022-05-252018Weiner, J., Maertzdorf, J., Sutherland, J. S., Duffy, F. J., Thompson, E., Suliman, S., ... & Kaufmann, S. H. (2018). Metabolite changes in blood predict the onset of tuberculosis. Nature communications, 9(1), 1-12.https://doi.org/10.1038/s41467-018-07635-72041-1723https://nru.uncst.go.ug/handle/123456789/3330New biomarkers of tuberculosis (TB) risk and disease are critical for the urgently needed control of the ongoing TB pandemic. In a prospective multisite study across Subsaharan Africa, we analyzed metabolic profiles in serum and plasma from HIV-negative, TB-exposed individuals who either progressed to TB 3–24 months post-exposure (progressors) or remained healthy (controls). We generated a trans-African metabolic biosignature for TB, which identifies future progressors both on blinded test samples and in external data sets and shows a performance of 69% sensitivity at 75% specificity in samples within 5 months of diagnosis. These prognostic metabolic signatures are consistent with development of subclinical disease prior to manifestation of active TB. Metabolic changes associated with pre-symptomatic disease are observed as early as 12 months prior to TB diagnosis, thus enabling timely interventions to prevent disease progression and transmission.enDiagnostic markers, Metabolomics, Predictive medicine, TuberculosisArticle