Damme, Lut VanGovinden, RoshiniMirembe, Florence M.Guédou, FernandSolomon, SunitiBecker, Marissa L.Pradeep, B.S.Krishnan, A.K.Alary, MichelPande, BinaRamjee, GitaDeese, JenniferCrucitti, TaniaTaylor, Doug2022-01-212022-01-212008Van Damme, L., Govinden, R., Mirembe, F. M., Guédou, F., Solomon, S., Becker, M. L., ... & Taylor, D. (2008). Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission. New England Journal of Medicine, 359(5), 463-472.https://www.nejm.org/doi/full/10.1056/NEJMoa0707957https://nru.uncst.go.ug/xmlui/handle/123456789/1406Women make up more than 50% of adults living with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa. Thus, female-initiated HIV prevention methods are urgently needed. Methods We performed a randomized, double-blind, placebo-controlled trial of cellulose sulfate, an HIV-entry inhibitor formulated as a vaginal gel, involving women at high risk for HIV infection at three African and two Indian sites. The primary end point was newly acquired infection with HIV type 1 or 2. The secondary end point was newly acquired gonococcal or chlamydial infection. The primary analysis was based on a log-rank test of no difference in the distribution of time to HIV infection, stratified according to site.enCellulose Sulfate GelPreventionVaginal HIV TransmissionArticle