Omujal, FrancisTenda, Kibira IreneLutoti, StephenKirabo, IreneKasango, Simon DembeNambatya, Kyeyune Grace2022-03-092022-03-092020Omujal, F., Tenda, K. I., Lutoti, S., Kirabo, I., Kasango, S. D., & Nambatya, K. G. (2020). Phytochemistry and anti-inflammatory activity of ethanolic root bark extract of Vepris nobilis Mziray (Rutaceae family). Scientific African, 9, e00484.https://doi.org/10.1016/j.sciaf.2020.e004842468-2276https://nru.uncst.go.ug/xmlui/handle/123456789/2618Root bark powder of Vepris nobilis Mziray (family Rutaceae) collected from Mukura Sub-county, Ngora District, Eastern Uganda, about 300 km from the Capital City Kampala was extracted with 70% ethanol. Phytochemical analyses was carried out as well as in vivo anti inflammatory animal tests. The GC–MS analysis identified 37 compounds in the extract including fatty acids (45.08%), sesquiterpenes (40.38%), furaquinoline alkaloids (10.93%), a phenylpropanoid (2.37%) and a triterpenoid (1.31%). Interestingly, it revealed that at 400 and 600 mg of extract / kg of body weight, formalin induced paw oedema in mice was inhibited much better than by 25 mg of Diclofenac sodium /kg body weight. It was concluded that ethanolic root bark extract of V. nobilis has important phytochemicals that need to be evaluated for anti-inflammatory activity as potential lead compounds for anti-inflammatory drug development.enVepris nobilis,Teclea nobilis,Root bark extract,Phytochemical,Anti-inflammatory activityArticle